Guideline:
Delirium and acute problematic behavior in the long-term care setting
Bibliographic Source(s)
- American Medical Directors Association (AMDA). Delirium and acute problematic behavior in the long-term care setting. Columbia (MD): American Medical Directors Association (AMDA); 2008. 36 p. [36 references]
Guideline Status
This is the current release of the guideline.
This guideline updates a previous version: American Medical Directors Association (AMDA). Altered mental states. Columbia (MD): American Medical Directors Association (AMDA); 1998. 20 p.
Guideline Category
Diagnosis
Evaluation
Management
Risk Assessment
Treatment
Intended Users
Advanced Practice Nurses
Allied Health Personnel
Nurses
Pharmacists
Physician Assistants
Physicians
Social Workers
Guideline Objective(s)
- To improve the quality of care delivered to patients in long-term care facilities
- To offer care providers and practitioners in long-term care facilities a systematic approach to recognizing assessing treating and monitoring patients with delirium and acute problematic behavior
Target Population
Elderly residents of long-term care facilities with delirium or acute problematic behavior
Interventions and Practices Considered
Recognition/Assessment
- Identification of the patient's problematic behavior and altered mental function including delirium (assessment of symptoms medical history medications; use of Confusion Assessment Method [CAM] instrument and diagnostic criteria for delirium)
- Assessment of individual risk factors for problematic behavior and delirium
- Determination of the urgency of the situation and the need for additional evaluation and testing
- Identification of the cause(s) of problematic behavior and altered mental function
- Assessment of medical illnesses and conditions that can affect behavior such as medication-related adverse consequences fluid or electrolyte imbalance infections acute renal or hepatic failure head trauma myocardial infarction stroke and others
- Use of laboratory tests including electrolytes blood urea nitrogen (BUN) glucose creatinine complete blood count (CBC) chest x-ray urinalysis electrocardiogram (EKG) serum vitamin B12 level and others
- Consideration of possible psychiatric illnesses such as psychosis mood disorders and personality disorders and dementia-related causes
Management/Treatment
- Initiation of a care plan for treatment
- Provision of symptomatic and cause-specific management
- Administration of medications such as antipsychotics antidepressants cholinesterase inhibitors and memantine anticonvulsants and anxiolytics
Monitoring
- Monitoring and adjustment of interventions as indicated
- Reviewing the effectiveness and appropriateness of medications
- Prevention identification and addressing of any complications of the conditions and treatments
Major Outcomes Considered
Benefits and risks of treatment
Methods Used to Collect/Select Evidence
Searches of Electronic Databases
Description of Methods used to Collect/Select the Evidence
Not stated
Number of Source Documents
Not stated
Methods Used to Assess the Quality and Strength of the Evidence
Expert Consensus
Rating Scheme for the Strength of the Evidence
Not applicable
Methods Used to Analyze the Evidence
Review
Description of the Methods Used to Analyze the Evidence
Not stated
Methods Used to Formulate the Recommendations
Expert Consensus
Description of Methods Used to Formulate the Recommendations
The guideline was developed by an interdisciplinary workgroup using a process that combined evidence- and consensus-based approaches. The workgroup included practitioners and others involved in patient care in long-term care facilities. Beginning with a general guideline developed by an agency association or organization such as the Agency for Healthcare Research and Quality (AHRQ) pertinent articles and information and a draft outline the group worked to make a concise usable guideline that is tailored to the long-term care setting. Because scientific research in the long-term care population is limited many recommendations were based on the expert opinion of practitioners in the field.
Rating Scheme for the Strength of the Recommendations
Not applicable
Cost Analysis
A formal cost analysis was not performed and published cost analyses were not reviewed.
Method of Guideline Validation
External Peer Review
Internal Peer Review
Description of Method of Guideline Validation
Guideline revisions were completed under the direction of the Clinical Practice Guideline Steering Committee. The committee incorporated information published in peer-reviewed journals after the original guidelines appeared as well as comments and recommendations not only from experts in the field addressed by the guideline but also from "hands-on" long-term care practitioners and staff.
All American Medical Directors Association (AMDA) clinical practice guidelines undergo external review. The draft guideline is sent to approximately 175+ reviewers. These reviewers include AMDA physician members and independent physicians specialists nurse practitioners pharmacists nurses consultants in the specified area and organizations that are knowledgeable of the guideline topic and the long-term care setting.
Major Recommendations
The algorithm Delirium and Acute Problematic Behavior in the Long-Term Care Setting is to be used in conjunction with the clinical practice guideline. The numbers next to the different components of the algorithm correspond with the steps in the text. Refer to the "Guideline Availability" field for information on obtaining the full text guideline.
Clinical Algorithm(s)
A clinical algorithm is provided for Delirium and Acute Problematic Behavior in the Long-Term Care Setting.
Type of Evidence supporting the Recommendations
The type of evidence supporting the recommendations is not specifically stated.
The guideline was developed by an interdisciplinary work group using a process that combined evidence- and consensus-based thinking.
Potential Benefits
Following the steps in this guideline should permit facilities and their staff and practitioners to:
- Optimize their approach to problematic behavior and delirium.
- Prevent unnecessary hospitalizations.
- Avoid over-reliance on psychiatric consultation for problematic behavior or altered mental function that might harm the patient if it substitutes for or delays recognition and management of medical causes.
Potential Harms
Hospitalization of patients with problematic behavior and delirium may be traumatic for the patient. Hospital staff may not be familiar with the patient's history and symptoms understand what triggers the problematic behavior or be aware of the environment in which the patient functions. Frequently hospitalization omits vital supportive care or relevant nonpharmacologic approaches and may result in undesirable changes in the patient's medication regimen. Many patients have a recurrence of problematic behavior after hospitalization and repeat hospital transfers may not be any more helpful.
Adverse Effects of Medications
- Unwarranted or unnecessarily prolonged antibiotic treatment is a widespread concern. Antibiotics can lead to additional complications (e.g. anorexia- or diarrhea-related fluid loss) that can contribute to impaired mental function or to the development of resistant organisms.
- All antipsychotics should be used cautiously and their risks identified and documented in patients with cerebrovascular risk factors. Patients who have dementia with Lewy bodies generally have an increased sensitivity to antipsychotics. Second-generation antipsychotics may have a lower frequency of extrapyramidal side effects such as parkinsonism or tardive dyskinesia but all antipsychotics have some significant associated risks. Also antipsychotics may exacerbate symptoms in patients with Lewy body dementia. All antipsychotic medications have the potential to induce akathisia a sense of motor restlessness that can result in pacing physical agitation and complaints of leg and thigh discomfort.
- In April 2005 the FDA issued an overall health advisory concerning an increased risk of death in patients with dementia who are treated with second-generation (so-called "atypical") antipsychotics. This warning has since been expanded to include all antipsychotic medications. For example warnings about the use of haloperidol have been revised to include cases of sudden death due to impairment of cardiac conduction in patients treated with this agent especially when the medication is given intravenously (a common but hazardous off-label use) or at doses higher than recommended.
- When inappropriately prescribed for patients with problematic behavior due to other causes antidepressants may exacerbate symptoms. Excessive serotonin stimulation due to selective serotonin reuptake inhibitors (SSRIs alone or in combination with other medications that affect serotonin levels) can lead to agitation delirium seizures other psychiatric symptoms or death ("serotonin syndrome"). The concurrent use of several antidepressants for diverse symptoms (e.g. depression anxiety pain appetite stimulation and insomnia) may also increase the risk for adverse consequences such as falls and serotonin syndrome. Unless another medication in the same class is being substituted withdrawing antidepressants too rapidly may cause behavioral symptoms that can be mistaken for a return of the underlying condition.
- Adverse consequences of cholinesterase inhibitors can include hallucinations confusion and agitation and those for memantine may include fatigue headache and hypertension. Cholinesterase inhibitors can also cause anorexia and other gastrointestinal symptoms that eventually lead to weight loss.
- Medications with anticholinergic effects can cause problematic behavior and may counteract the effectiveness of cholinesterase inhibitors. Therefore it is important to review the medication regimen and reduce or eliminate medications with anticholinergic properties or side effects whether or not cholinesterase inhibitors are being given.
- Divalproex sodium and other earlier-generation anticonvulsants are associated with significant side effects such as sedation. Lamotrigine may have fewer significant side effects than the earlier-generation anticonvulsants.
- Inappropriate use of benzodiazepines to try to manage patients with delirium and psychosis may permit symptoms to progress and may lead to the use of additional inappropriate and ineffective medications or to avoidable hospitalization. All benzodiazepines are associated to some degree with adverse consequences such as increased confusion sedation falls and hip fractures in a susceptible population. In addition they may cause increased agitation insomnia and other side effects. Tolerance occurs rapidly with short half-life benzodiazepines. Short-half-life benzodiazepines such as lorazepam which are often used to treat patients with psychosis delirium and nonspecific agitated or combative behavior are best avoided. They are often ineffective and commonly cause oversedation and "rebound" effects (anxiety and insomnia) after each dose.
Qualifying Statements
- This clinical practice guideline is provided for discussion and educational purposes only and should not be used or in any way relied upon without consultation with and supervision of a qualified physician based on the case history and medical condition of a particular patient. The American Medical Directors Association (AMDA) and the American Health Care Association their heirs executors administrators successors and assigns hereby disclaim any and all liability for damages of whatever kind resulting from the use negligent or otherwise of this clinical practice guideline.
- The utilization of the AMDA's Clinical Practice Guideline does not preclude compliance with State and Federal regulation as well as facility policies and procedures. They are not substitutes for the experience and judgment of clinicians and caregivers. The Clinical Practice Guidelines are not to be considered as standards of care but are developed to enhance the clinicians' ability to practice.
- AMDA guidelines emphasize key care processes and are organized for ready incorporation into facility-specific policies and procedures to guide staff and practitioner practices and performance. They are meant to be used in a manner appropriate to the population and practice of a particular facility.
Description of Implementation Strategy
The implementation of this clinical practice guideline (CPG) is outlined in four phases. Each phase presents a series of steps which should be carried out in the process of implementing the practices presented in this guideline. Each phase is summarized below.
- Recognition
- Define the area of improvement and determine if there is a CPG available for the defined area. Then evaluate the pertinence and feasibility of implementing the CPG
- Assessment
- Define the functions necessary for implementation and then educate and train staff. Assess and document performance and outcome indicators and then develop a system to measure outcomes
- Implementation
- Identify and document how each step of the CPG will be carried out and develop an implementation timetable
- Identify individual responsible for each step of the CPG
- Identify support systems that impact the direct care
- Educate and train appropriate individuals in specific CPG implementation and then implement the CPG
- Monitoring
- Evaluate performance based on relevant indicators and identify areas for improvement
- Evaluate the predefined performance measures and obtain and provide feedback
Guideline implementation will be affected by resources available in the facility including staffing and will require the involvement of all those in the facility who have a role in patient care.
Implementation Tools
Clinical Algorithm
For information about availability see the "Availability of Companion Documents" and "Patient Resources" fields below.
IOM Care Need
Getting Better
Living with Illness
IOM Domain
Effectiveness
Patient-centeredness
Bibliographic Source(s)
- American Medical Directors Association (AMDA). Delirium and acute problematic behavior in the long-term care setting. Columbia (MD): American Medical Directors Association (AMDA); 2008. 36 p. [36 references]
Adaptation
Not applicable: The guideline was not adapted from another source.
Guideline Developer Comment
Organizational participants included:
- American Association of Homes and Services for the Aging
- American College of Health Care Administrators
- American Geriatrics Society
- American Health Care Association
- American Society of Consultant Pharmacists
- National Association of Directors of Nursing Administration in Long-Term Care
- National Association of Geriatric Nursing Assistants
- National Conference of Gerontological Nurse Practitioners
Source(s) of Funding
Not stated
Guideline Committee
Steering Committee
Composition of Group that Authored the Guideline
Committee Members: Lisa Cantrell RN C; Charles Cefalu MD MS; Sherrie Dornberger RNC CDONA FDONA; Sandra Fitzler RN; Joseph Gruber RPh FASCP CGP; Susan M. Levy MD CMD; Evvie F. Munley; Jonathan Musher MD CMD; Barbara Resnick PhD CRNP; William Simonson Pharm.D. FASCP CGP; Marianna Grachek MSN CNHA CALA
Financial Disclosures/Conflicts of Interest
Not stated
Guideline Status
This is the current release of the guideline.
This guideline updates a previous version: American Medical Directors Association (AMDA). Altered mental states. Columbia (MD): American Medical Directors Association (AMDA); 1998. 20 p.
Guideline Availability
Electronic copies: None available
Print copies: Available from the American Medical Directors Association 10480 Little Patuxent Pkwy Suite 760 Columbia MD 21044. Telephone: (800) 876-2632 or (410) 740-9743; Fax (410) 740-4572. Web site: www.amda.com.
Availability of Companion Documents
None available
Patient Resources
None available
NGC STATUS
This summary was completed by ECRI on July 12 1999. The information was verified by the American Medical Directors Association as of August 8 1999. This summary was updated by ECRI Institute on May 20 2008.
COPYRIGHT STATEMENT
This NGC summary is based on the original guideline which is copyrighted by the American Medical Directors Association (AMDA) and the American Health Care Association. Written permission from AMDA must be obtained to duplicate or disseminate information from the original guideline. For more information contact AMDA at (410) 740-9743.
NGC Disclaimer
The National Guideline Clearinghouse™ (NGC) does not develop produce approve or endorse the guidelines represented on this site.
All guidelines summarized by NGC and hosted on our site are produced under the auspices of medical specialty societies relevant professional associations public or private organizations other government agencies health care organizations or plans and similar entities.
Guidelines represented on the NGC Web site are submitted by guideline developers and are screened solely to determine that they meet the NGC Inclusion Criteria which may be found at http://www.guideline.gov/about/inclusion.aspx .
NGC AHRQ and its contractor ECRI Institute make no warranties concerning the content or clinical efficacy or effectiveness of the clinical practice guidelines and related materials represented on this site. Moreover the views and opinions of developers or authors of guidelines represented on this site do not necessarily state or reflect those of NGC AHRQ or its contractor ECRI Institute and inclusion or hosting of guidelines in NGC may not be used for advertising or commercial endorsement purposes.
Readers with questions regarding guideline content are directed to contact the guideline developer.
Tools
No Quick Reference tools have been developed.