Glaucoma: Screening -- Adults


General

Grade: I The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of the service. Evidence is lacking, of poor quality, or conflicting, and the balance of benefits and harms cannot be determined. Read the clinical considerations section of USPSTF Recommendation Statement. If the service is offered, patients should understand the uncertainty about the balance of benefits and harms.

Specific Recommendations

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for primary open-angle glaucoma (POAG) in adults.

Frequency of Service

No information available.

Risk Factor Information

Increased IOP, family history of glaucoma, older age, and African American race increase a person's risk for open-angle glaucoma. Recent evidence shows that glaucoma may be increased in Hispanics. Older African Americans have a higher prevalence of glaucoma and perhaps a more rapid disease progression; if screening reduces vision impairment, then African Americans would probably have greater absolute benefit than whites.


Clinical

Patient Population Under Consideration

This recommendation applies to adults who do not have vision symptoms who are seen in a primary care setting.

Assessment of Risk

Increased IOP, family history of glaucoma, older age, and African American race increase a person's risk for open-angle glaucoma. Recent evidence shows that glaucoma may be increased in Hispanics. Older African Americans have a higher prevalence of glaucoma and perhaps a more rapid disease progression; if screening reduces vision impairment, then African Americans would probably have greater absolute benefit than whites.

Screening Tests

Diagnosis of POAG is based on a combination of tests showing characteristic degenerative changes in the optic disc and defects in visual fields (often loss in peripheral vision). Although increased IOP was previously considered an important part of the definition of this condition, it is now known that many persons with POAG do not have increased IOP and not all persons with increased IOP have or will develop glaucoma. Therefore, screening with tonometry alone may be inadequate to detect all cases of POAG.Measurement of visual fields can be difficult. The reliability of a single measurement may be low; several consistent measurements are needed to establish the presence of defects. Specialists use dilated ophthalmoscopy or slit lamp examination to evaluate changes in the optic disc; however, even experts have varying ability to detect glaucomatous progression of the optic disc. In addition, no single standard exists to define and measure progression of visual field defects. Most tests that are available in a primary care setting do not have acceptable accuracy to detect glaucoma.

Treatment

The initial aim and efficacy assessment of primary treatments of POAG are reduction of IOP. Treatments include medication, laser therapy, and surgery. These treatments also effectively reduce the longer-term development and progression of small visual field defects as assessed by clinical examination. However, the magnitude of the effectiveness in reducing impairments in patient-reported, vision-related function, including development of blindness, is uncertain.

Suggestions for Practice Regarding the I Statement

Potential Preventable Burden

Approximately 2.5 million persons in the United States have glaucoma, and approximately 1.9% of adults older than 40 years have open-angle glaucoma. Most persons with glaucoma have POAG. This condition is defined as optic neuropathy with a visibly open anterior chamber angle (between the iris and the anterior sclera or peripheral cornea) that is associated with progressive death of retinal ganglion cells and axons and visual field loss.The goal of screening programs is to identify and treat POAG before visual impairment develops. The proportion of persons who are currently unidentified and who will develop vision problems as a result of a diagnosis obtained through screening is not known. The natural history of glaucoma is heterogeneous and poorly defined.In some persons, POAG does not progress or progression is so slow that it never has an important effect on vision. The size of this subgroup is uncertain and may depend on the ethnicity and age of the population and initial findings of ophthalmologic testing. Screening in asymptomatic persons is likely to increase the size of this subgroup. Other patients have more rapid progression, as determined by optic nerve damage, visual field defects, and development of visual impairment.Whether early glaucoma will progress to visual impairment cannot be precisely predicted. Whether the rate of progression of visual field defects remains uniform throughout the course of glaucoma is also not known. Older adults and African Americans seem to be at increased risk and have more rapid progression. Persons with a short life expectancy probably have little to gain from glaucoma screening.

Potential Harms

Harms caused by treatment of glaucoma include formation of cataracts and those resulting from surgery and from topical medications. Overdiagnosis and overtreatment are possible because not all persons who are diagnosed with and treated for glaucoma progress to visual impairment; the magnitude of overdiagnosis and overtreatment is unknown.

Costs

The cost of screening varies widely depending on the tests used. Testing with hand-held tonometers and ophthalmoscopes can be done quickly and inexpensively. However, the diagnostic accuracy of these inexpensive tests is not known. According to the National Business Group on Health, the average screening eye examination costs $71. Screening with specialized tests for glaucoma and with newer computerized instruments is more expensive.

Current Practice

Approximately 62% of Medicare patients enrolled in an HMO were screened for glaucoma in 2009. In 2008, approximately 53% of whites, 47% of African Americans, and 37% of Hispanics reported an annual eye care visit.

Other Considerations

Research Needs and Gaps

The natural history of glaucoma, particularly the role of IOP and its relationship to optic nerve damage, visual field defects, visual impairment, and blindness, is poorly understood. More evidence is needed on the link between the intermediate glaucoma outcomes of optic nerve damage and visual field loss and the final health outcomes of visual disability and patient-reported outcomes. Evidence for screening would ideally come from a randomized, controlled trial of routine (or targeted) screening versus standard care with long-term follow-up. More studies on treatment that are of adequate duration and size to assess important clinical outcomes (such as visual impairment and vision-related quality of life), or at least greater changes in visual fields, are needed.

Rationale

No information available.


Others

The American Academy of Ophthalmology recommends a comprehensive adult medical eye evaluation, including tests for glaucoma, with frequency depending on the patient's age and other risk factors for glaucoma. The American Optometric Association recommends eye examinations every 1 to 2 years, with frequency depending on age and risk factors for glaucoma.


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