Treatment for Brain Metastases
Key Points
Key Points
In the United States, it is estimated that between 8% and 10% of patients with cancer will develop brain metastases representing ~200,000 new patients with brain metastases every year.
The most likely primary cancers to seed brain metastases are melanoma, lung adenocarcinoma, and those from lung, breast, melanoma, renal, kidney, esophagus, and, head and neck.
This guideline was developed by a multi-disciplinary team of medical oncologists, neurosurgeons, neuro-oncologists and radiation oncologists, and it integrates the latest evidence supporting the use of surgery, radiation, and medical therapies for patients with CNS metastases.
Treatment
...eatment...
Recommendation 1.1Surgery may be offered...
....2Where surgery is considered, no recom...
Recommendation 1.3No recommendation can be m...
...mmendation 2.1Patients with symptomat...
...ation 2.2For patients with asympto...
Recommendation 2.3 Osimertinib or icotinib may...
Recommendation 2.4Alectinib, briga...
...ndation 2.5Pembrolizumab may be offered to patien...
...mmendation 2.6Ipilimumab plus nivolumab (fo...
...commendation 2.7The combination of tucati...
...endation 3.1Radiation therapy should not be...
...3.2SRS alone (as opposed to WBRT o...
...ion 3.3SRS alone should be offered to p...
...ation 3.4SRS, WBRT, and the combination of S...
...ion 3.5Memantine and hippocampal avoidance...
...tion 3.6Radiation sensitizing agents...
...dation 4.1For patients who will receive both radi...
...eves that cancer clinical trials are vital to in...