Stage III Non-Small Cell Lung Cancer
Key Points
Key Points
- Stage III non-small cell lung cancer (NSCLC) represents one of the most heterogenous subgroups of lung cancer. Consequently, it is also the subgroup in which choice and sequence of multimodality treatment varies significantly among clinicians, with variations being observed across and within institutes.
- This guideline reviews the published evidence addressing diagnosis and management of stage III NSCLC and provides evidence-based guidance on the common clinical dilemmas that clinicians may have while evaluating a patient with suspected or known stage III NSCLC.
- Three randomized control trials (RCTs) were published in 2022 and 2023 and prompted an amendment to the 2021 guideline.
Diagnosis
...gnosis...
...uation and Stagin...
...endation 1.1For patients with suspected stage III...
...1.2Following evaluation with CT scan as...
...on 1.3For patients with suspected stage III NSCL...
...tion 1.4For patients who require pathologi...
...mmendation 1.5For patients who require pat...
....6For patients who have suspected or confirme...
...e PointBiopsy should generally be performed...
Treatment
...atment...
Surge...
...ommendation 2.1For patients with stage IIIA (...
...2.2(Update): Patients with stage III NSCLC...
...Practice Points...
...ts with stage III NSCLC generally should...
...esence of oncogenic driver alterations, av...
...and providers should consider enrollment on cl...
...oadjuvant Therapy
....1Patients who are planned for a multimodality a...
...mmendation 3.2(Update): Patients with st...
...dation 3.3For patients with resectable supe...
...juvant Therapy
...dation 4.1Patients with resected stage III NS...
...ecommendation 4.2(Update): Patients with r...
...ion 4.3For patients with completely resect...
...ectable Disease...
...endation 5.1Patients with stage III NSCLC...
...endation 5.2Concurrent chemotherapy delivered wit...
...5.3Patients with stage III NSCLC wh...
...5.4Patients with stage III NSCLC receiv...
...5.5Doses higher than 60 Gy and up...
....6Patients with stage III NSCLC re...
...5.7Patients with stage III NSCLC receiv...
...1. Evaluation and Staging in Stage III NS...
...2. Management of Stage III NSCLCArrows with dotte...