Clear Cell Renal Cell Carcinoma
Key Points
Key Points
- Kidney cancer will be diagnosed in 79,000 U.S. patients in 2022 and will account for 13,920 deaths.
- Opportunities for extended survival and even durable disease control in the metastatic setting have recently appeared as novel classes of therapeutics, reshaping the trajectory of this cancer.
- This rapid evolution has paved the way for this first set of comprehensive guidelines for treating metastatic clear cell renal cell carcinoma (ccRCC).
Diagnosis
...gnosis...
...ion 1.1The diagnosis of metastatic clear cell rena...
...endation 1.2Radiographic diagnosis...
Treatment
...eatment...
...endation 2.1Select patients (see Practi...
....1Select patients with metastatic clear cel...
...rst-Line Treatmenta Select cases (see Recomm...
...ndation 3.2All patients with metastati...
...3.3Patients with favorable risk disease who...
...ation 3.4Select patients with metastatic...
...ecommendation 3.5The use of high dose inte...
...ion from 2023 Rapid Recommendation...
...ion 3.6Treatment with IpiNivoCabo is not reco...
...ommendation 4.1Nivolumab or cabozantinib should...
...commendation 4.2Patients progressing on comb...
...dation 4.3Patients who progress aft...
...ommendation 4.4For patients on immun...
...commendation 5.1For patients with l...
...mendation 5.2For patients undergoing comple...
...ation 6.1.1Patients with symptomat...
...tion 6.1.2Patients with bone metastases from meta...
...gure 2. Second-Line or Greater Tre...
...Metastases-Directed Treatment...
...ommendation 6.1.3No recommendation regardi...
...6.2.1Patients with brain metastases from metastat...
...mmendation 6.2.2No recommendation regar...
...commendation 6.3Patients with metastatic c...
...Special Patient Subtypes...
...ASCO believes that cancer clinical tri...