Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation

If the maternal antibody screen is positive or unknown because the mother did not have prenatal antibody screening, the infant should have a direct antiglobulin test (DAT) and the infant’s blood type should be determined as soon as possible using either cord or peripheral blood. (B, R)

Use TSB as the definitive test to guide phototherapy and escalation-of-care decisions, including exchange transfusion. (X, R)