Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk

Publication Date: July 31, 2019

Key Points

Key Points

Individuals should be screened for metabolic risk, in five categories:
  • Elevated waist circumference
  • Decreased high density lipoprotein (HDL) cholesterol
  • Elevated serum triglycerides
  • Elevated blood pressure
  • Elevated blood glucose
Three or more categories being abnormal should alert the clinician to a patient’s increased risk for atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus (T2DM) (i.e., metabolic risk).

Endocrine Society (ES) recommends that providers measure waist circumference as part of the initial evaluation. (Note: However, that this does not replace the measurement of weight.)

Behavioral change should be the first-line therapy for prevention and should include changes to diet, increased exercise, and weight loss.

Persons identified as having metabolic risk should undergo risk scoring to identify the 10-year risk for ASCVD.

Diagnosis

Diagnosi...

...itions and Diagnosis...

...In individuals aged 40–75 years in the offi...

...uals aged 40–75 years in the offi...

....3: To establish metabolic risk in the gene...

...individuals previously diagnosed w...

...ends that all individuals at metabolic risk...

...or individuals with elevated blood press...

...1. Criteria Proposed for Clinical Diagnosi...

...Flow Chart for the Assessment and Tr...

...e 2. Measuring Waist Circumference Accord...

...nded Waist Thresholds to Define Abd...

...3. Definitions of Prediabetes (Intermediat...


Treatment

...reatme...

...festyle and Behavioral...

...ndividuals at metabolic risk, ES recommends tha...

...viduals at metabolic risk with exces...

...individuals at metabolic risk, ES recom...

...viduals at metabolic risk, ES recommends...

...Effect of Lifestyle Components on Metab...

...omponents of Healthy Cardiovascular Dietary Patter...

...le 6. Nutrient Action Nutrient Action...


...l and Pharmacological Therapy...

...sment and Evaluation...

...individuals identified as having metabolic risk,...

...In individuals with low density li...

...terol Reduction...

...duals 40–75 years of age with LDL-C â‰...

...In individuals 40–75 years of age with L...

....4.1: In individuals 40–75 years of...

...In individuals 40–75 years of age without dia...

....3: In individuals with metabolic risk...

....4: In individuals aged >75 years without...

...In individuals at metabolic risk wh...

...6: In individuals aged 40 years and ol...

...e 7. Statin TherapyHaving trouble...

...8. Treatment Recommendations and LDL-C Goals for T...

...ood Pressure Reduction...

...n individuals with blood pressure above...

...viduals without a history of ASCVD with metabolic...

...g Progression to Type 2 Diabetes...

...In individuals with prediabetes, ES recom...

...viduals with prediabetes who have limita...