Hypercalcemia of Malignancy in Adults
Key Points
Key Points
- Hypercalcemia of malignancy (HCM), a condition associated with high morbidity and mortality, is the most common metabolic complication of malignancies.
- All adults with HCM should receive treatment with denosumab (Dmab) or an intravenous (IV) bisphosphonate (BP).
- Adults with calcitriol-mediated HCM should first be treated with glucocorticoids, with the addition of Dmab or an IV BP if glucocorticoid therapy is insufficient.
Treatment
...atment...
...mendation 1In adults with HCM, Endocrine Societ...
...ommendation 2In adults with HCM, ES suggests trea...
...3In adults with severe HCM (serum cal...
...ecommendation 4In adults with refract...
...n 5In adults with HCM from tumors associated wit...
...ation 6In adult patients with hypercalcem...
...mendation 7In adult patients with hyper...
...dation 8In adult patients with hyp...
...Practice Statements...
...lts with HCM, adequate hydration with IV f...
...n adults with HCM, dental hygiene and oral...
...adults with HCM who receive antire...
...with HCM, renal function (creatinine...
...adults with HCM and renal insufficiency...
...n adults with HCM, serum magnesium and p...
...In adults with HCM, clinical oncology consultat...
...with hypercalcemia due to parathyroid...
...nt Regimens for Hypercalcemia of Mal...
...gure 1. Suggested Workflow for the Managem...
...Common Terminology Criteria for Adverse Ev...