Treatment of Latent Tuberculosis Infection
Publication Date: February 14, 2020
Last Updated: March 14, 2022
Recommendations for regimens to treat latent tuberculosis infection
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| Priority rank* | Regimen | Recommendation (strong or conditional) |
Evidence (high, moderate, low, or very low) |
|---|---|---|---|
| Preferred | 3 mos isoniazid plus rifapentine given once weekly | Strong | Moderate |
| Preferred | 4 mos rifampin given daily | Strong | Moderate (HIV negative)† |
| Preferred | 3 mos isoniazid plus rifampin given daily | Conditional | Very low (HIV negative) |
| Conditional | Low (HIV positive) | ||
| Alternative | 6 mos isoniazid given daily | Strong§ | Moderate (HIV negative) |
| Conditional | Moderate (HIV positive) | ||
| Alternative | 9 mos isoniazid given daily | Conditional | Moderate |
* Preferred: excellent tolerability and efficacy, shorter treatment duration, higher completion rates than longer regimens and therefore higher effectiveness; alternative: excellent efficacy but concerns regarding longer treatment duration, lower completion rates, and therefore lower effectiveness.
† No evidence reported in HIV-positive persons.
§ Strong recommendation for those persons unable to take a preferred regimen (e.g., due to drug intolerability or drug-drug interactions).
† No evidence reported in HIV-positive persons.
§ Strong recommendation for those persons unable to take a preferred regimen (e.g., due to drug intolerability or drug-drug interactions).
Recommendation Grading
Overview
Title
Treatment of Latent Tuberculosis Infection
Authoring Organization
Centers for Disease Control and Prevention
Publication Month/Year
February 14, 2020
Last Updated Month/Year
February 5, 2024
Supplemental Implementation Tools
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Inclusion Criteria
Female, Male, Adolescent, Adult, Child, Infant, Older adult
Health Care Settings
Emergency care, Hospital
Intended Users
Epidemiology infection prevention, nurse, nurse practitioner, physician, physician assistant
Scope
Management, Treatment
Diseases/Conditions (MeSH)
D014376 - Tuberculosis
Keywords
tuberculosis, Mycobacterium tuberculosis, latent tuberculosis infection, Tuberculosis
Source Citation
Sterling TR, Njie G, Zenner D, et al. Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020. MMWR Recomm Rep 2020;69(No. RR-1):1–11. DOI: http://dx.doi.org/10.15585/mmwr.rr6901a1