Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids
Publication Date: July 28, 2023
Last Updated: November 14, 2024
Summary of Key Questions and Clinical Considerations
What Specific Clinical Situations Favor Use of Low- or High-Dose Buprenorphine Initiation Strategies?
- Observational data suggest buprenorphine initiation is best individualized by setting and patient preference.
- LDB-OC in hospital settings appears to be well tolerated in observational data.
- More evidence is needed to determine the optimal strategy for LDB-OC in ambulatory settings for patients who are ineligible for medically prescribed FAO under current regulations.
- In patients with chronic exposure to HPSO who initiate buprenorphine after opioid abstinence and development of OWS, rapid dose escalation has been observed to be safe, primarily in the ED setting.
Title
Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids
Authoring Organization
American Society of Addiction Medicine