Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

Publication Date: 2024 May 03


Full Text Sources

Elsevier Science (Free)

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Authors

Bin Bao; Youyuan Wang; Pavl Boudreau; Xinyang Song; Meng Wu; Xi Chen; Izabel Patik; Ying Tang; Jodie Ouahed; Amit Ringel; Jared Barends; Chuan Wu; Emily Balskus; Jay Thiagarajah; Jian Liu; Michael R Wessels; Wayne Isaac Lencer; Dennis L Kasper; Dingding An; Bruce Harold Horwitz; Scott B Snapper

Abstract

OBJECTIVE

Gut bacterial sphingolipids, primarily produced by Bacteroidetes, have dual roles as bacterial virulence factors and regulators of the host mucosal immune system, including regulatory T cells and invariant natural killer T cells. Patients with inflammatory bowel disease display altered sphingolipids profiles in fecal samples. However, how bacterial sphingolipids modulate mucosal homeostasis and regulate intestinal inflammation remains unclear.


Source

Cellular and molecular gastroenterology and hepatology


Pub Types(s)

Journal Article


Language

English


PubMed ID

38704148