Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

Publication Date: 2024 May 03

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Bin Bao; Youyuan Wang; Pavl Boudreau; Xinyang Song; Meng Wu; Xi Chen; Izabel Patik; Ying Tang; Jodie Ouahed; Amit Ringel; Jared Barends; Chuan Wu; Emily Balskus; Jay Thiagarajah; Jian Liu; Michael R Wessels; Wayne Isaac Lencer; Dennis L Kasper; Dingding An; Bruce Harold Horwitz; Scott B Snapper



Gut bacterial sphingolipids, primarily produced by Bacteroidetes, have dual roles as bacterial virulence factors and regulators of the host mucosal immune system, including regulatory T cells and invariant natural killer T cells. Patients with inflammatory bowel disease display altered sphingolipids profiles in fecal samples. However, how bacterial sphingolipids modulate mucosal homeostasis and regulate intestinal inflammation remains unclear.


Cellular and molecular gastroenterology and hepatology

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