A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and 'bad apple' effect on clinical trajectory.

Publication Date: 2024 May 21


Full Text Sources

Elsevier Science (Free)

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Authors

Jianbin Chen; Neslihan Arife Kaya; Ying Zhang; Raden Indah Kendarsari; Karthik Sekar; Shay Lee Chong; Veerabrahma Pratap Seshachalam; Wen Huan Ling; Cheryl Zi Jin Phua; Hannah Lai; Hechuan Yang; Bingxin Lu; Jia Qi Lim; Siming Ma; Sin Chi Chew; Khi Pin Chua; Jacob Josiah Santiago Alvarez; Lingyan Wu; London Ooi; Alexander Yaw-Fui Chung; Peng Chung Cheow; Juinn Huar Kam; Alfred Wei-Chieh Kow; Iyer Shridhar Ganpathi; Chairat Bunchaliew; Jidapa Thammasiri; Peng Soon Koh; Diana Bee-Lan Ong; Jasmine Lim; Vanessa H de Villa; Rouchelle D Dela Cruz; Tracy Jiezhen Loh; Wei Keat Wan; Wei Qiang Leow; Yi Yang; Jin Liu; Anders Jacobsen Skanderup; Yin Huei Pang; Gwyneth Shook Ting Soon; Krishnakumar Madhavan; Tony Kiat-Hon Lim; Glenn Bonney; Brian K P Goh; Valerie Chew; Yock Young Dan; Han Chong Toh; Roger Sik-Yin Foo; Wai Leong Tam; Weiwei Zhai; Pierce Kah-Hoe Chow

Abstract

OBJECTIVE

Hepatocellular Carcinoma (HCC) is a highly fatal cancer characterized by high intra-tumor heterogeneity (ITH). A panoramic understanding of its tumor evolution, in relation to its clinical trajectory, may provide novel prognostic and treatment strategies.


Source

Journal of hepatology


Pub Types(s)

Journal Article


Language

English


PubMed ID

38782118