Clinical Utility of Sperm DNA Integrity Testing
Publication Date: March 1, 2013
Last Updated: March 14, 2022
Recommendations
There is fair evidence that increased DNA fragmentation is associated with reduced fertility. (, B)
323908
There is insufficient evidence to use the DNA integrity test as a predictor of fertility since cut-points have not been clearly established and validated. (C)
323908
There is insufficient evidence to recommend the use of DNA integrity tests to predict pregnancy with IUI. (C)
323908
There is insufficient evidence to recommend routine use of DNA integrity testing for patients undergoing IVF/ICSI. (C)
323908
There is insufficient evidence to recommend routine DNA integrity testing to predict pregnancy loss. (C)
323908
There is insufficient evidence to recommend the routine use of sperm DNA integrity tests in the evaluation and treatment of the infertile couple. (, C)
323908
Recommendation Grading
Overview
Title
Clinical Utility of Sperm DNA Integrity Testing
Authoring Organization
American Society for Reproductive Medicine
Publication Month/Year
March 1, 2013
Last Updated Month/Year
January 9, 2024
Document Type
Guideline
External Publication Status
Published
Country of Publication
US
Document Objectives
Sperm DNA damage is more common in infertile men and may contribute to poor reproductive performance. However, current methods for assessing sperm DNA integrity do not reliably predict treatment outcomes and cannot be recommended routinely for clinical use.
Inclusion Criteria
Male, Adult
Health Care Settings
Ambulatory, Outpatient
Intended Users
Nurse, nurse practitioner, physician, physician assistant
Scope
Assessment and screening, Diagnosis
Diseases/Conditions (MeSH)
D007246 - Infertility, D005826 - Genetics, Medical, D007248 - Infertility, Male
Keywords
infertility, Reproductive Health