AST to Platelet Ratio Index (APRI) Calculator Clinical Calculator and Pathways - Guideline Central

AST to Platelet Ratio Index (APRI) Calculator

This is an AST to Platelet Ratio Index calculator tool. Enter the required values to calculate the APRI value. The APRI Score will appear in the oval on the far right (highlighted in yellow). Most laboratories use 40 IU/L as the value for the AST upper limit of normal.

Interpretation:

In a meta-analysis of 40 studies, investigators concluded that an APRI cuttoff of 1.0 had a sensitivity of 76% and specificity of 72% for predicting cirrhosis. Similarly, an APRI cuttoff of 0.7 had a sensitivity of 77% and specificity of 72% for predicting significant hepatic fibrosis.

Source: Lin ZH, Xin YN, Dong QJ, et al. Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: an updated meta-analysis. Hepatology. 2011;53:726-36.
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