Melphalan, Prednisone, and Thalidomide or Lenalidomide in Treating Patients With Newly Diagnosed Multiple Myeloma

Recruitment Status
ACTIVE, NOT RECRUITING - HAS RESULTS
(See Contacts and Locations)Verified January 2026 by National Cancer Institute (NCI)
Sponsor
National Cancer Institute (NCI)
Information Provided by (Responsible Party)
National Cancer Institute (NCI)
Clinicaltrials.gov Identifier
NCT00602641
Other Study ID Numbers:
NCI-2009-00522
First Submitted
January 17, 2008
First Posted
January 27, 2008
Results First Posted
May 4, 2015
Last Update Posted
May 28, 2026
Last Verified
January 2026

ClinicalTrials.gov processed this data on May 2026. Link to the current ClinicalTrials.gov record .

History of Changes

Study Details

Study Description

PRIMARY OBJECTIVES:

I. To compare progression-free survival between patients receiving melphalan, prednisone, and thalidomide versus melphalan, prednisone, and lenalidomide in newly diagnosed multiple myeloma patients who are not candidates for high-dose therapy.

SECONDARY OBJECTIVES:

I. To compare overall survival between the arms. II. To compare response rates and depth of response. III. To compare the incidence of toxicities. IV. To validate the translocation classification (TC) of myeloma as a prognostic tool using gene expression profiling at diagnosis.

TERTIARY OBJECTIVES:

I. To compare quality-of-life (QOL) change between arms based on the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT-Ntx) Trial Outcome Index (TOI) from registration (prior to initiation of treatment) to the end of cycle 24 (maintenance therapy).

II. To examine the impact of differential treatment response (PFS), if observed, on QOL based on the FACT-Ntx TOI up to cycle 38 (maintenance therapy).

III. To obtain prospective data on myeloma specific QOL attributes.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I:

INDUCTION THERAPY: Patients receive melphalan orally (PO) and prednisone PO once daily (QD) on days 1-4, and thalidomide PO QD on days 1-28. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity.

MAINTENANCE THERAPY: Patients receive thalidomide PO QD and continue in the absence of disease progression.

ARM II:

INDUCTION THERAPY: Patients receive melphalan PO and prednisone PO QD on days 1-4, and lenalidomide PO on days 1-21. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity.

MAINTENANCE THERAPY: Patients receive lenalidomide PO QD on days 1-21. Courses repeat every 28 days in the absence of disease progression.

After completion of study treatment, patients are followed up periodically for 10 years.

Condition or DiseaseIntervention/Treatment
Multiple Myeloma
Other: Laboratory Biomarker AnalysisOther: Laboratory Biomarker Analysis

Study Design

Study TypeInterventional
Actual Enrollment306 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingNone (Open Label)
Primary PurposeTreatment
Official TitleAn Intergroup Phase III Randomized Controlled Trial Comparing Melphalan, Prednisone and Thalidomide (MPT) Versus Melphalan, Prednisone and Lenalidomide (Revlimid(TM))(MPR) in Newly Diagnosed Multiple Myeloma Patients Who Are Not Candidates for High-Dose Therapy
Study Start DateFebruary 28, 2008
Actual Primary Completion DateJanuary 17, 2014
Actual Study Completion Date8mos 1w from now

Groups and Cohorts

Group/CohortIntervention/Treatment
Arm I (thalidomide)
INDUCTION THERAPY: Patients receive melphalan PO and prednisone PO QD on days 1-4, and thalidomide PO QD on days 1-28. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive thalidomide PO QD and continue in the absence of disease progression.
Other: Laboratory Biomarker Analysis
Optional correlative studies
Arm II (lenalidomide)
INDUCTION THERAPY: Patients receive melphalan PO and prednisone PO QD on days 1-4, and lenalidomide PO on days 1-21. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive lenalidomide PO QD on days 1-21. Courses repeat every 28 days in the absence of disease progression.
Other: Laboratory Biomarker Analysis
Optional correlative studies

Outcome Measures

Primary Outcome Measures
  1. Progression-Free Survival (PFS)
    PFS is defined as the time from randomization to the earlier of progression or death of any cause.
Secondary Outcome Measures
  1. Overall Survival
    Overall survival was defined as time from randomization to death from any cause.
  2. Very Good Partial Response (VGPR) Rate
    Response evaluation was based on the International Myeloma Working Group (IMWG) response criteria. VGPR rate was defined as patients achieving at least VGPR which include patients who achieving complete response (CR) and VGPR. CR refers to patients who have complete disappearance of an M-protein and no evidence of myeloma in the bone marrow. VGPR refers to patients who meet the following criteria: Serum and urine M-component detectable by immunofixation but not on electrophoresis; Or 90% or greater reduction in serum M-component plus urine M-component \<100 mg per 24 hours; If the serum and urine M protein are unmeasurable and the immunoglobulin free light chain parameter is being used to measure response, a ≥ 90% decrease in the difference between involved and uninvolved free light chain (FLC) levels is required in place of the M protein criteria.
  3. Change in Functional Assessment of Cancer Therapy-Neurotoxicity Trial Outcome Index (FACT-Ntx TOI) Score From Baseline to Cycle 12
    A combined scale was used to assess the quality of life (QOL) comprising of the well established and validated functional well-being (FWB) and physical well-being (PWB) components of FACT-G version 4 (14 questions), which will address the physical and functional well-being of multiple myeloma patients plus the FACT-neurotoxicity (NTX, 11 questions), which will evaluate symptoms of neurotoxicity. This pooled scale is referred to as the FACT Ntx TOI. The FACT-Ntx TOI has 25 items and the score ranges from 0 (worst possible outcome) to 100 (best possible outcome).

Eligibility Criteria

Ages Eligible for Study(Adult, Older Adult)
Sexes Eligible for StudyAll
Accepts Healthy VolunteersNo
Inclusion Criteria
Patients must have a confirmed diagnosis of symptomatic myeloma; for the original diagnosis of myeloma patients should have met the following criteria at one point in their disease course:
Bone marrow plasmacytosis with \>= 10% plasma cells or sheets of plasma cells or biopsy proven plasmacytoma
Patient must have had symptomatic disease at initial diagnosis that prompted the initiation of therapy as well as evidence of end-organ damage at the time of diagnosis namely; at least one of the following: anemia, hypercalcemia, bone disease (lytic bone lesions or pathologic fracture), or renal dysfunction
NOTE: Patients with asymptomatic smoldering myeloma (serum m protein \>= 3 gm/dL or bone marrow plasma cells \>= 10% or greater plus no evidence of anemia, hypercalcemia, lytic bone lesions or renal dysfunction) and monoclonal gammopathy of undetermined significance (serum m protein \< 3 gm/dL and bone marrow plasma cells \< 10% plus no evidence of anemia, hypercalcemia, lytic bone lesions or renal dysfunction) are not eligible
Patients must be \> 65 and have declined alternative treatment OR patients who are \>= 18 \< 65 are eligible if they:
Are not a candidate for autologous stem cell transplantation in the opinion of the treating physician OR
Have declined transplant or other alternative treatment
Eastern Cooperative Oncology Group (ECOG) performance status =\< 2
All tests below must be performed within 28 days prior to randomization:
Serum free light chain assay
Kappa free light chain
Lambda free light chain
NOTE: The serum free light chain test is required to be done if the patient does not have measurable disease in the serum or urine; measurable disease in the serum is defined as having a serum M-spike \>= 1 g/dL; measurable disease in the urine is defined as having a urine M-spike \>= 200 mg/24 hr
NOTE: urine protein electrophoresis (UPEP) (on a 24 hour collection) is required, no substitute method is acceptable; urine must be followed monthly if the baseline urine M-spike is \>= 200 mg/24 hr; please note that if both serum and urine m-components are present, both must be followed in order to evaluate response
Hemoglobin \> 7 g/dL
Platelet count \> 75,000 cells/mm\^3
Absolute neutrophil count \> 1000 cells/mm\^3
Creatinine \< 2.5 mg/dL and creatinine clearance (measured or calculated) \> 60 mL/min
Total bilirubin =\< 1.5 mg/dL
Serum glutamate pyruvate transaminase (SGPT) \[alanine aminotransferase (ALT)\] and serum glutamic oxaloacetic transaminase (SGOT) \[aspartate aminotransferase (AST)\] =\< 2.5 times the upper limit of normal
Patients must be previously untreated for myeloma, although prior treatment for myeloma with prednisone or dexamethasone for less than 4 weeks total dosing alone or in combination with thalidomide or lenalidomide for less than 2 weeks total dosing is allowable
Patients may be receiving bisphosphonates or growth factors (erythropoietin) for multiple myeloma; although erythropoietin is allowed, it is strongly discouraged due to increased risk of thrombosis when employed alongside thalidomide and/or lenalidomide therapy
Patients must be willing and able to take prophylaxis with either aspirin at 325 mg/day or alternative prophylaxis with either low molecular weight heparin or Coumadin
Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10 - 14 days and again within 24 hours prior to starting cycle 1 of lenalidomide; further, they must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy; a FCBP is a sexually mature woman who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); all patients must be counseled by a trained counselor every 28 days about pregnancy precautions and risks of fetal exposure
Patients must not have uncontrolled inter-current illness that would limit compliance with the study including:
Uncontrolled hypertension
Symptomatic congestive heart failure
Unstable angina
Uncontrolled cardiac arrhythmia
Uncontrolled psychiatric illness or social situation
Prior history of Stevens Johnson syndrome
Patients must not have grade 2 or higher peripheral neuropathy
Patients must not have an active, uncontrolled infection
Female patients MUST NOT be pregnant or breastfeeding; the use of these drugs in this patient population is ABSOLUTELY CONTRAINDICATED; for women of childbearing potential, a negative serum pregnancy test is required within 10-14 days prior to randomization; for female patients of childbearing potential a negative serum pregnancy test must be repeated within 24 hours prior to initiation of treatment, weekly for the first 4 weeks of treatment and then every 4 weeks if the patient's periods are regular or every 2 weeks if they are not; women of childbearing potential must be willing to refrain from sexual intercourse or must be willing to employ a dual method of contraception, one of which is highly effective \[intrauterine device (IUD), birth control pills, tubal ligation or partner's vasectomy\] and another additional method (condom, diaphragm or cervical cap) starting 4 weeks prior to and while taking lenalidomide and thalidomide and for four weeks after discontinuing this therapy; the male partner of a female using a single form of birth control should use a condom regardless of his vasectomy status
Sexually active males must be willing to use a condom (even if they have undergone a prior vasectomy) while having intercourse with any woman, while taking lenalidomide and thalidomide and for 4 weeks after stopping treatment
Patients must not have had a second active malignancy requiring treatment within the last 2 years, with the exceptions of basal or squamous cell carcinoma of the skin, in situ carcinoma of the cervix
Exclusion Criteria
Inclusion Criteria:
Patients must have a confirmed diagnosis of symptomatic myeloma; for the original diagnosis of myeloma patients should have met the following criteria at one point in their disease course:
Bone marrow plasmacytosis with \>= 10% plasma cells or sheets of plasma cells or biopsy proven plasmacytoma
Patient must have had symptomatic disease at initial diagnosis that prompted the initiation of therapy as well as evidence of end-organ damage at the time of diagnosis namely; at least one of the following: anemia, hypercalcemia, bone disease (lytic bone lesions or pathologic fracture), or renal dysfunction
NOTE: Patients with asymptomatic smoldering myeloma (serum m protein \>= 3 gm/dL or bone marrow plasma cells \>= 10% or greater plus no evidence of anemia, hypercalcemia, lytic bone lesions or renal dysfunction) and monoclonal gammopathy of undetermined significance (serum m protein \< 3 gm/dL and bone marrow plasma cells \< 10% plus no evidence of anemia, hypercalcemia, lytic bone lesions or renal dysfunction) are not eligible
Patients must be \> 65 and have declined alternative treatment OR patients who are \>= 18 \< 65 are eligible if they:
Are not a candidate for autologous stem cell transplantation in the opinion of the treating physician OR
Have declined transplant or other alternative treatment
Eastern Cooperative Oncology Group (ECOG) performance status =\< 2
All tests below must be performed within 28 days prior to randomization:
Serum free light chain assay
Kappa free light chain
Lambda free light chain
NOTE: The serum free light chain test is required to be done if the patient does not have measurable disease in the serum or urine; measurable disease in the serum is defined as having a serum M-spike \>= 1 g/dL; measurable disease in the urine is defined as having a urine M-spike \>= 200 mg/24 hr
NOTE: urine protein electrophoresis (UPEP) (on a 24 hour collection) is required, no substitute method is acceptable; urine must be followed monthly if the baseline urine M-spike is \>= 200 mg/24 hr; please note that if both serum and urine m-components are present, both must be followed in order to evaluate response
Hemoglobin \> 7 g/dL
Platelet count \> 75,000 cells/mm\^3
Absolute neutrophil count \> 1000 cells/mm\^3
Creatinine \< 2.5 mg/dL and creatinine clearance (measured or calculated) \> 60 mL/min
Total bilirubin =\< 1.5 mg/dL
Serum glutamate pyruvate transaminase (SGPT) \[alanine aminotransferase (ALT)\] and serum glutamic oxaloacetic transaminase (SGOT) \[aspartate aminotransferase (AST)\] =\< 2.5 times the upper limit of normal
Patients must be previously untreated for myeloma, although prior treatment for myeloma with prednisone or dexamethasone for less than 4 weeks total dosing alone or in combination with thalidomide or lenalidomide for less than 2 weeks total dosing is allowable
Patients may be receiving bisphosphonates or growth factors (erythropoietin) for multiple myeloma; although erythropoietin is allowed, it is strongly discouraged due to increased risk of thrombosis when employed alongside thalidomide and/or lenalidomide therapy
Patients must be willing and able to take prophylaxis with either aspirin at 325 mg/day or alternative prophylaxis with either low molecular weight heparin or Coumadin
Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10 - 14 days and again within 24 hours prior to starting cycle 1 of lenalidomide; further, they must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy; a FCBP is a sexually mature woman who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); all patients must be counseled by a trained counselor every 28 days about pregnancy precautions and risks of fetal exposure
Patients must not have uncontrolled inter-current illness that would limit compliance with the study including:
Uncontrolled hypertension
Symptomatic congestive heart failure
Unstable angina
Uncontrolled cardiac arrhythmia
Uncontrolled psychiatric illness or social situation
Prior history of Stevens Johnson syndrome
Patients must not have grade 2 or higher peripheral neuropathy
Patients must not have an active, uncontrolled infection
Female patients MUST NOT be pregnant or breastfeeding; the use of these drugs in this patient population is ABSOLUTELY CONTRAINDICATED; for women of childbearing potential, a negative serum pregnancy test is required within 10-14 days prior to randomization; for female patients of childbearing potential a negative serum pregnancy test must be repeated within 24 hours prior to initiation of treatment, weekly for the first 4 weeks of treatment and then every 4 weeks if the patient's periods are regular or every 2 weeks if they are not; women of childbearing potential must be willing to refrain from sexual intercourse or must be willing to employ a dual method of contraception, one of which is highly effective \[intrauterine device (IUD), birth control pills, tubal ligation or partner's vasectomy\] and another additional method (condom, diaphragm or cervical cap) starting 4 weeks prior to and while taking lenalidomide and thalidomide and for four weeks after discontinuing this therapy; the male partner of a female using a single form of birth control should use a condom regardless of his vasectomy status
Sexually active males must be willing to use a condom (even if they have undergone a prior vasectomy) while having intercourse with any woman, while taking lenalidomide and thalidomide and for 4 weeks after stopping treatment
Patients must not have had a second active malignancy requiring treatment within the last 2 years, with the exceptions of basal or squamous cell carcinoma of the skin, in situ carcinoma of the cervix

Contacts and Locations

Sponsors and CollaboratorsNational Cancer Institute (NCI)
Locations
Providence Hospital | Mobile Alabama, United States, 36608Mayo Clinic in Arizona | Scottsdale Arizona, United States, 85259Sparks Regional Medical Center | Fort Smith Arkansas, United States, 72901UC San Diego Moores Cancer Center | La Jolla California, United States, 92093Fremont - Rideout Cancer Center | Marysville California, United States, 95901Memorial Medical Center | Modesto California, United States, 95355University of California Davis Comprehensive Cancer Center | Sacramento California, United States, 95817UC San Diego Medical Center - Hillcrest | San Diego California, United States, 92103Kaiser Permanente-San Diego Mission | San Diego California, United States, 92108San Diego VA Medical Center | San Diego California, United States, 92161Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee California, United States, 96161The Medical Center of Aurora | Aurora Colorado, United States, 80012Boulder Community Foothills Hospital | Boulder Colorado, United States, 80303Penrose-Saint Francis Healthcare | Colorado Springs Colorado, United States, 80907AdventHealth Porter | Denver Colorado, United States, 80210Presbyterian - Saint Lukes Medical Center - Health One | Denver Colorado, United States, 80218Saint Joseph Hospital - Cancer Centers of Colorado | Denver Colorado, United States, 80218Rose Medical Center | Denver Colorado, United States, 80220Western States Cancer Research NCORP | Denver Colorado, United States, 80222Swedish Medical Center | Englewood Colorado, United States, 80113Poudre Valley Hospital | Fort Collins Colorado, United States, 80524Saint Mary's Hospital and Regional Medical Center | Grand Junction Colorado, United States, 81501Banner North Colorado Medical Center | Greeley Colorado, United States, 80631CommonSpirit Saint Anthony Hospital Cancer Center | Lakewood Colorado, United States, 80228Sky Ridge Medical Center | Lone Tree Colorado, United States, 80124Longmont United Hospital | Longmont Colorado, United States, 80501Banner North Colorado Medical Center - Loveland Campus | Loveland Colorado, United States, 80539Saint Mary Corwin Medical Center | Pueblo Colorado, United States, 81004North Suburban Medical Center | Thornton Colorado, United States, 80229Intermountain Health Lutheran Hospital | Wheat Ridge Colorado, United States, 80401Hartford Hospital | Hartford Connecticut, United States, 06102MedStar Georgetown University Hospital | Washington D.C. District of Columbia, United States, 20007Holy Cross Hospital | Fort Lauderdale Florida, United States, 33308Broward Health Medical Center | Fort Lauderdale Florida, United States, 33316Mayo Clinic in Florida | Jacksonville Florida, United States, 32224-9980Jupiter Medical Center | Jupiter Florida, United States, 33458Mount Sinai Medical Center | Miami Beach Florida, United States, 33140Phoebe Putney Memorial Hospital | Albany Georgia, United States, 31701Piedmont Hospital | Atlanta Georgia, United States, 30309Emory University Hospital/Winship Cancer Institute | Atlanta Georgia, United States, 30322Atlanta Regional CCOP | Atlanta Georgia, United States, 30342Emory Saint Joseph's Hospital | Atlanta Georgia, United States, 30342Northside Hospital | Atlanta Georgia, United States, 30342Augusta University Medical Center | Augusta Georgia, United States, 30912WellStar Cobb Hospital | Austell Georgia, United States, 30106John B Amos Cancer Center | Columbus Georgia, United States, 31904Emory Decatur Hospital | Decatur Georgia, United States, 30033Dublin Hematology Oncology Care PC | Dublin Georgia, United States, 31021Piedmont Fayette Hospital | Fayetteville Georgia, United States, 30214Northside Hospital - Gwinnett | Lawrenceville Georgia, United States, 30046Wellstar Kennestone Hospital | Marietta Georgia, United States, 30060Southern Regional Medical Center | Riverdale Georgia, United States, 30274Harbin Clinic Medical Oncology and Clinical Research | Rome Georgia, United States, 30165OSF Saint Anthony's Health Center | Alton Illinois, United States, 62002Rush-Copley Medical Center | Aurora Illinois, United States, 60504OSF Saint Joseph Medical Center | Bloomington Illinois, United States, 61701Illinois CancerCare-Bloomington | Bloomington Illinois, United States, 61704Graham Hospital Association | Canton Illinois, United States, 61520Illinois CancerCare-Canton | Canton Illinois, United States, 61520Illinois CancerCare-Carthage | Carthage Illinois, United States, 62321Memorial Hospital | Carthage Illinois, United States, 62321Mount Sinai Hospital Medical Center | Chicago Illinois, United States, 60608University of Illinois | Chicago Illinois, United States, 60612Swedish Covenant Hospital | Chicago Illinois, United States, 60625University of Chicago Comprehensive Cancer Center | Chicago Illinois, United States, 60637Heartland Cancer Research NCORP | Decatur Illinois, United States, 62526Eureka Hospital | Eureka Illinois, United States, 61530Illinois CancerCare-Eureka | Eureka Illinois, United States, 61530NorthShore University HealthSystem-Evanston Hospital | Evanston Illinois, United States, 60201Saint Francis Hospital | Evanston Illinois, United States, 60202Galesburg Cottage Hospital | Galesburg Illinois, United States, 61401Illinois CancerCare-Cottage | Galesburg Illinois, United States, 61401Illinois CancerCare-Galesburg | Galesburg Illinois, United States, 61401Western Illinois Cancer Treatment Center | Galesburg Illinois, United States, 61401Illinois CancerCare-Havana | Havana Illinois, United States, 62644Mason District Hospital | Havana Illinois, United States, 62644Hinsdale Hematology Oncology Associates Incorporated | Hinsdale Illinois, United States, 60521Hopedale Medical Complex - Hospital | Hopedale Illinois, United States, 61747Duly Health and Care Joliet | Joliet Illinois, United States, 60435Illinois CancerCare-Kewanee Clinic | Kewanee Illinois, United States, 61443Kewanee Hospital | Kewanee Illinois, United States, 61443AMITA Health Adventist Medical Center | La Grange Illinois, United States, 60525Illinois CancerCare-Macomb | Macomb Illinois, United States, 61455Mcdonough District Hospital | Macomb Illinois, United States, 61455Garneau, Stewart C MD (UIA Investigator) | Moline Illinois, United States, 61265Porubcin, Michael MD (UIA Investigator) | Moline Illinois, United States, 61265Sharis, Christine M MD (UIA Investigator) | Moline Illinois, United States, 61265Spector, David MD (UIA Investigator) | Moline Illinois, United States, 61265Stoffel, Thomas J MD (UIA Investigator) | Moline Illinois, United States, 61265Trinity Medical Center | Moline Illinois, United States, 61265Holy Family Medical Center | Monmouth Illinois, United States, 61462Illinois CancerCare-Monmouth | Monmouth Illinois, United States, 61462SSM Health Good Samaritan | Mount Vernon Illinois, United States, 62864Carle BroMenn Medical Center | Normal Illinois, United States, 61761Carle Cancer Institute Normal | Normal Illinois, United States, 61761Illinois CancerCare-Community Cancer Center | Normal Illinois, United States, 61761Illinois CancerCare-Ottawa Clinic | Ottawa Illinois, United States, 61350Ottawa Regional Hospital and Healthcare Center | Ottawa Illinois, United States, 61350Illinois CancerCare-Pekin | Pekin Illinois, United States, 61554OSF Saint Francis Radiation Oncology at Pekin | Pekin Illinois, United States, 61554Pekin Hospital | Pekin Illinois, United States, 61554Proctor Hospital | Peoria Illinois, United States, 61614Illinois CancerCare-Peoria | Peoria Illinois, United States, 61615Methodist Medical Center of Illinois | Peoria Illinois, United States, 61636OSF Saint Francis Medical Center | Peoria Illinois, United States, 61637Illinois CancerCare-Peru | Peru Illinois, United States, 61354Illinois Valley Hospital | Peru Illinois, United States, 61354Valley Radiation Oncology | Peru Illinois, United States, 61354Illinois CancerCare-Princeton | Princeton Illinois, United States, 61356Perry Memorial Hospital | Princeton Illinois, United States, 61356Swedish American Hospital | Rockford Illinois, United States, 61104Illinois CancerCare-Spring Valley | Spring Valley Illinois, United States, 61362Saint Margaret's Hospital | Spring Valley Illinois, United States, 61362Springfield Memorial Hospital | Springfield Illinois, United States, 62781Carle Cancer Center | Urbana Illinois, United States, 61801Franciscan Saint Francis Health-Beech Grove | Beech Grove Indiana, United States, 46107IU Health Arnett Cancer Care | Lafayette Indiana, United States, 47904Franciscan Saint Anthony Health-Michigan City | Michigan City Indiana, United States, 46360The Community Hospital | Munster Indiana, United States, 46321Reid Health | Richmond Indiana, United States, 47374McFarland Clinic - Ames | Ames Iowa, United States, 50010Constantinou, Costas L MD (UIA Investigator) | Bettendorf Iowa, United States, 52722University of Iowa Healthcare Cancer Services Quad Cities | Bettendorf Iowa, United States, 52722UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive Iowa, United States, 50325MercyOne Genesis Davenport Medical Center | Davenport Iowa, United States, 52803MercyOne Genesis Davenport Cancer Center | Davenport Iowa, United States, 52804Mercy Capitol | Des Moines Iowa, United States, 50307Iowa Methodist Medical Center | Des Moines Iowa, United States, 50309Iowa-Wide Oncology Research Coalition NCORP | Des Moines Iowa, United States, 50309UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines Iowa, United States, 50309Mercy Medical Center - Des Moines | Des Moines Iowa, United States, 50314UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines Iowa, United States, 50314Iowa Lutheran Hospital | Des Moines Iowa, United States, 50316University of Iowa/Holden Comprehensive Cancer Center | Iowa City Iowa, United States, 52242Iowa City VA Healthcare System | Iowa City Iowa, United States, 52246Mercy Medical Center - North Iowa | Mason City Iowa, United States, 50401Ottumwa Regional Health Center | Ottumwa Iowa, United States, 52501Siouxland Regional Cancer Center | Sioux City Iowa, United States, 51101Mercy Medical Center-Sioux City | Sioux City Iowa, United States, 51102Saint Luke's Regional Medical Center | Sioux City Iowa, United States, 51104Cedar Valley Medical Specialists | Waterloo Iowa, United States, 50701MercyOne Waterloo Cancer Center | Waterloo Iowa, United States, 50702Lawrence Memorial Hospital | Lawrence Kansas, United States, 66044Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka Kansas, United States, 66606Wesley Medical Center | Wichita Kansas, United States, 67214Doctors Carrol, Sheth, Raghavan | Louisville Kentucky, United States, 40215Owensboro Health Mitchell Memorial Cancer Center | Owensboro Kentucky, United States, 42303Ochsner Health Center-Summa | Baton Rouge Louisiana, United States, 70809Ochsner Health Center-Covington | Covington Louisiana, United States, 70433Ochsner Medical Center Jefferson | New Orleans Louisiana, United States, 70121Mercy Hospital | Portland Maine, United States, 04101Greater Baltimore Medical Center | Baltimore Maryland, United States, 21204Walter Reed National Military Medical Center | Bethesda Maryland, United States, 20889-5600Lahey Hospital and Medical Center | Burlington Massachusetts, United States, 01805Addison Gilbert Hospital | Gloucester Massachusetts, United States, 01930Michigan Cancer Research Consortium NCORP | Ann Arbor Michigan, United States, 48106Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor Michigan, United States, 48106Corewell Health Dearborn Hospital | Dearborn Michigan, United States, 48124Henry Ford Health Saint John Hospital | Detroit Michigan, United States, 48236Hurley Medical Center | Flint Michigan, United States, 48503Genesys Regional Medical Center-West Flint Campus | Flint Michigan, United States, 48532Allegiance Health | Jackson Michigan, United States, 49201Bronson Methodist Hospital | Kalamazoo Michigan, United States, 49007West Michigan Cancer Center | Kalamazoo Michigan, United States, 49007Beacon Kalamazoo | Kalamazoo Michigan, United States, 49048University of Michigan Health - Sparrow Lansing | Lansing Michigan, United States, 48912Trinity Health Saint Mary Mercy Livonia Hospital | Livonia Michigan, United States, 48154Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac Michigan, United States, 48341Lake Huron Medical Center | Port Huron Michigan, United States, 48060MyMichigan Medical Center Saginaw | Saginaw Michigan, United States, 48601Henry Ford Health Warren Hospital | Warren Michigan, United States, 48093Sanford Joe Lueken Cancer Center | Bemidji Minnesota, United States, 56601Essentia Health Saint Joseph's Medical Center | Brainerd Minnesota, United States, 56401Fairview Ridges Hospital | Burnsville Minnesota, United States, 55337Mercy Hospital | Coon Rapids Minnesota, United States, 55433Essentia Health Cancer Center | Duluth Minnesota, United States, 55805Essentia Health Saint Mary's Medical Center | Duluth Minnesota, United States, 55805Miller-Dwan Hospital | Duluth Minnesota, United States, 55805Fairview Southdale Hospital | Edina Minnesota, United States, 55435Lake Region Healthcare Corporation-Cancer Care | Fergus Falls Minnesota, United States, 56537Unity Hospital | Fridley Minnesota, United States, 55432Hutchinson Area Health Care | Hutchinson Minnesota, United States, 55350Meeker County Memorial Hospital | Litchfield Minnesota, United States, 55355Minnesota Oncology Hematology PA-Maplewood | Maplewood Minnesota, United States, 55109Saint John's Hospital - Healtheast | Maplewood Minnesota, United States, 55109Abbott-Northwestern Hospital | Minneapolis Minnesota, United States, 55407Virginia Piper Cancer Institute | Minneapolis Minnesota, United States, 55407Hennepin County Medical Center | Minneapolis Minnesota, United States, 55415Minneapolis VA Medical Center | Minneapolis Minnesota, United States, 55417North Memorial Medical Health Center | Robbinsdale Minnesota, United States, 55422Mayo Clinic in Rochester | Rochester Minnesota, United States, 55905Metro Minnesota Community Oncology Research Consortium | Saint Louis Park Minnesota, United States, 55416Park Nicollet Clinic - Saint Louis Park | Saint Louis Park Minnesota, United States, 55416Regions Hospital | Saint Paul Minnesota, United States, 55101Saint Joseph's Hospital - Healtheast | Saint Paul Minnesota, United States, 55102United Hospital | Saint Paul Minnesota, United States, 55102Saint Francis Regional Medical Center | Shakopee Minnesota, United States, 55379Lakeview Hospital | Stillwater Minnesota, United States, 55082Ridgeview Medical Center | Waconia Minnesota, United States, 55387Rice Memorial Hospital | Willmar Minnesota, United States, 56201Fairview Cancer Center - Woodbury | Woodbury Minnesota, United States, 55125Minnesota Oncology Hematology PA-Woodbury | Woodbury Minnesota, United States, 55125Singing River Hospital | Pascagoula Mississippi, United States, 39581Central Care Cancer Center - Bolivar | Bolivar Missouri, United States, 65613Cox Cancer Center Branson | Branson Missouri, United States, 65616Southeast Missouri Hospital | Cape Girardeau Missouri, United States, 63701Mercy Cancer Center - Cape Girardeau | Cape Girardeau Missouri, United States, 63703Saint Francis Medical Center | Cape Girardeau Missouri, United States, 63703Saint Luke's Hospital | Chesterfield Missouri, United States, 63017MU Health Care Goldschmidt Cancer Center | Jefferson City Missouri, United States, 65109Cancer Research for the Ozarks NCORP | Springfield Missouri, United States, 65804Mercy Hospital Springfield | Springfield Missouri, United States, 65804CoxHealth South Hospital | Springfield Missouri, United States, 65807Mercy Infusion Center - Chippewa | St Louis Missouri, United States, 63109Missouri Baptist Medical Center | St Louis Missouri, United States, 63131Center for Cancer Care and Research | St Louis Missouri, United States, 63141Comprehensive Cancer Care PC | St Louis Missouri, United States, 63141Mercy Hospital Saint Louis | St Louis Missouri, United States, 63141Saint Louis-Cape Girardeau CCOP | St Louis Missouri, United States, 63141Billings Clinic Cancer Center | Billings Montana, United States, 59101Northern Rockies Radiation Oncology Center | Billings Montana, United States, 59101Saint Vincent Healthcare | Billings Montana, United States, 59101Montana Cancer Consortium NCORP | Billings Montana, United States, 59102Saint Vincent Frontier Cancer Center | Billings Montana, United States, 59102Bozeman Health Deaconess Hospital | Bozeman Montana, United States, 59715Saint James Community Hospital and Cancer Treatment Center | Butte Montana, United States, 59701Benefis Sletten Cancer Institute | Great Falls Montana, United States, 59405Berdeaux, Donald MD (UIA Investigator) | Great Falls Montana, United States, 59405Great Falls Clinic | Great Falls Montana, United States, 59405Northern Montana Hospital | Havre Montana, United States, 59501Saint Peter's Community Hospital | Helena Montana, United States, 59601Glacier Oncology PLLC | Kalispell Montana, United States, 59901Kalispell Medical Oncology | Kalispell Montana, United States, 59901Logan Health Medical Center | Kalispell Montana, United States, 59901Montana Cancer Specialists | Missoula Montana, United States, 59802Saint Patrick Hospital - Community Hospital | Missoula Montana, United States, 59802Community Medical Center | Missoula Montana, United States, 59804Guardian Oncology and Center for Wellness | Missoula Montana, United States, 59804CHI Health Good Samaritan | Kearney Nebraska, United States, 68847Nebraska Cancer Research Center | Lincoln Nebraska, United States, 68510Missouri Valley Cancer Consortium | Omaha Nebraska, United States, 68106Alegent Health Immanuel Medical Center | Omaha Nebraska, United States, 68122Alegent Health Bergan Mercy Medical Center | Omaha Nebraska, United States, 68124Creighton University Medical Center | Omaha Nebraska, United States, 68131University of Nebraska Medical Center | Omaha Nebraska, United States, 68198University Medical Center of Southern Nevada | Las Vegas Nevada, United States, 89102Nevada Cancer Research Foundation NCORP | Las Vegas Nevada, United States, 89120Nevada Cancer Institute-Summerlin Campus | Las Vegas Nevada, United States, 89135Veterans Adminstration New Jersey Health Care System | East Orange New Jersey, United States, 07018-1095Virtua Memorial | Mount Holly New Jersey, United States, 08060Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick New Jersey, United States, 08903Rutgers Cancer Institute of New Jersey | New Brunswick New Jersey, United States, 08903Rutgers New Jersey Medical School | Newark New Jersey, United States, 07101Virtua Voorhees | Voorhees Township New Jersey, United States, 08043Kings County Hospital | Brooklyn New York, United States, 11203State University of New York Downstate Medical Center | Brooklyn New York, United States, 11203Roswell Park Cancer Institute | Buffalo New York, United States, 14263Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse New York, United States, 13057Veterans Affairs New York Harbor Healthcare System-Manhattan Campus | New York New York, United States, 10010University of Rochester | Rochester New York, United States, 14642Stony Brook University Medical Center | Stony Brook New York, United States, 11794Syracuse Veterans Administration Medical Center | Syracuse New York, United States, 13210Montefiore Medical Center-Wakefield Campus | The Bronx New York, United States, 10466Novant Health Presbyterian Medical Center | Charlotte North Carolina, United States, 28204Southeastern Medical Oncology Center-Goldsboro | Goldsboro North Carolina, United States, 27534Wayne Memorial Hospital | Goldsboro North Carolina, United States, 27534Margaret R Pardee Memorial Hospital | Hendersonville North Carolina, United States, 28791ECU Health Oncology Kinston | Kinston North Carolina, United States, 28501UNC Health Cancer Care Raleigh | Raleigh North Carolina, United States, 27607Mid Dakota Clinic | Bismarck North Dakota, United States, 58501Saint Alexius Medical Center | Bismarck North Dakota, United States, 58501Sanford Bismarck Medical Center | Bismarck North Dakota, United States, 58501Sanford Broadway Medical Center | Fargo North Dakota, United States, 58122Summa Health System - Akron Campus | Akron Ohio, United States, 44304Summa Health System - Barberton Campus | Barberton Ohio, United States, 44203Mary Rutan Hospital | Bellefontaine Ohio, United States, 43311Cleveland Clinic Mercy Hospital | Canton Ohio, United States, 44708Aultman Health Foundation | Canton Ohio, United States, 44710Adena Regional Medical Center | Chillicothe Ohio, United States, 45601Case Western Reserve University | Cleveland Ohio, United States, 44106MetroHealth Medical Center | Cleveland Ohio, United States, 44109Riverside Methodist Hospital | Columbus Ohio, United States, 43214Columbus NCI Community Oncology Research Program | Columbus Ohio, United States, 43215Grant Medical Center | Columbus Ohio, United States, 43215Mount Carmel Health Center West | Columbus Ohio, United States, 43222Doctors Hospital | Columbus Ohio, United States, 43228Grandview Hospital | Dayton Ohio, United States, 45405Good Samaritan Hospital - Dayton | Dayton Ohio, United States, 45406Miami Valley Hospital | Dayton Ohio, United States, 45409Miami Valley Hospital North | Dayton Ohio, United States, 45415Dayton Veterans Affairs Medical Center | Dayton Ohio, United States, 45428Dayton NCI Community Oncology Research Program | Dayton Ohio, United States, 45459Grady Memorial Hospital | Delaware Ohio, United States, 43015Blanchard Valley Hospital | Findlay Ohio, United States, 45840Atrium Medical Center-Middletown Regional Hospital | Franklin Ohio, United States, 45005-1066Wayne Hospital | Greenville Ohio, United States, 45331Kettering Medical Center | Kettering Ohio, United States, 45429Fairfield Medical Center | Lancaster Ohio, United States, 43130Saint Rita's Medical Center | Lima Ohio, United States, 45801Marietta Memorial Hospital | Marietta Ohio, United States, 45750Knox Community Hospital | Mount Vernon Ohio, United States, 43050Licking Memorial Hospital | Newark Ohio, United States, 43055Springfield Regional Medical Center | Springfield Ohio, United States, 45504Upper Valley Medical Center | Troy Ohio, United States, 45373Saint Ann's Hospital | Westerville Ohio, United States, 43081Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center | Wilmington Ohio, United States, 45177Greene Memorial Hospital | Xenia Ohio, United States, 45385Genesis Healthcare System Cancer Care Center | Zanesville Ohio, United States, 43701Cancer Centers of Southwest Oklahoma Research | Lawton Oklahoma, United States, 73505Clackamas Radiation Oncology Center | Clackamas Oregon, United States, 97015Legacy Mount Hood Medical Center | Gresham Oregon, United States, 97030Providence Milwaukie Hospital | Milwaukie Oregon, United States, 97222Providence Newberg Medical Center | Newberg Oregon, United States, 97132Providence Willamette Falls Medical Center | Oregon City Oregon, United States, 97045Legacy Good Samaritan Hospital and Medical Center | Portland Oregon, United States, 97210Providence Portland Medical Center | Portland Oregon, United States, 97213Adventist Medical Center | Portland Oregon, United States, 97216Providence Saint Vincent Medical Center | Portland Oregon, United States, 97225Compass Oncology Rose Quarter | Portland Oregon, United States, 97227Legacy Emanuel Hospital and Health Center | Portland Oregon, United States, 97227Legacy Meridian Park Hospital | Tualatin Oregon, United States, 97062Bryn Mawr Hospital | Bryn Mawr Pennsylvania, United States, 19010Adams Cancer Center | Gettysburg Pennsylvania, United States, 17325WellSpan Medical Oncology and Hematology | Hanover Pennsylvania, United States, 17331Penn State Milton S Hershey Medical Center | Hershey Pennsylvania, United States, 17033-0850Central PA Hematology-Medical Oncology Associates PC | Lemoyne Pennsylvania, United States, 17043Lewistown Hospital | Lewistown Pennsylvania, United States, 17044Paoli Memorial Hospital | Paoli Pennsylvania, United States, 19301Einstein Medical Center Philadelphia | Philadelphia Pennsylvania, United States, 19141Reading Hospital McGlinn Cancer Institute at Phoenixville | Phoenixville Pennsylvania, United States, 19460Guthrie Medical Group PC-Robert Packer Hospital | Sayre Pennsylvania, United States, 18840Mount Nittany Medical Center | State College Pennsylvania, United States, 16803UPMC Susquehanna | Williamsport Pennsylvania, United States, 17701Lankenau Medical Center | Wynnewood Pennsylvania, United States, 19096Main Line Health NCORP | Wynnewood Pennsylvania, United States, 19096WellSpan Health-York Cancer Center | York Pennsylvania, United States, 17403WellSpan Health-York Hospital | York Pennsylvania, United States, 17403Rapid City Regional Hospital | Rapid City South Dakota, United States, 57701Sanford Cancer Center Oncology Clinic | Sioux Falls South Dakota, United States, 57104Avera Cancer Institute | Sioux Falls South Dakota, United States, 57105Medical X-Ray Center | Sioux Falls South Dakota, United States, 57105Avera McKennan Hospital and University Health Center | Sioux Falls South Dakota, United States, 57117-5045Sanford USD Medical Center - Sioux Falls | Sioux Falls South Dakota, United States, 57117-5134Cookeville Regional Medical Center | Cookeville Tennessee, United States, 38501Jackson-Madison County General Hospital | Jackson Tennessee, United States, 38301The Jackson Clinic PA | Jackson Tennessee, United States, 38301Vanderbilt University/Ingram Cancer Center | Nashville Tennessee, United States, 37232Scott and White Memorial Hospital | Temple Texas, United States, 76508University of Virginia Cancer Center | Charlottesville Virginia, United States, 22908Danville Regional Medical Center | Danville Virginia, United States, 24541Sovah Health Martinsville | Martinsville Virginia, United States, 24112MultiCare Auburn Medical Center | Auburn Washington, United States, 98001Providence Regional Cancer System-Centralia | Centralia Washington, United States, 98531Saint Francis Hospital | Federal Way Washington, United States, 98003Saint Clare Hospital | Lakewood Washington, United States, 98499Providence - Saint Peter Hospital | Olympia Washington, United States, 98506-5166MultiCare Good Samaritan Hospital | Puyallup Washington, United States, 98372Swedish Medical Center-First Hill | Seattle Washington, United States, 98122MultiCare Allenmore Hospital | Tacoma Washington, United States, 98405MultiCare Tacoma General Hospital | Tacoma Washington, United States, 98405Northwest NCI Community Oncology Research Program | Tacoma Washington, United States, 98405Saint Joseph Medical Center | Tacoma Washington, United States, 98405PeaceHealth Southwest Medical Center | Vancouver Washington, United States, 98664Legacy Salmon Creek Hospital | Vancouver Washington, United States, 98686West Virginia University Charleston Division | Charleston West Virginia, United States, 25304Camden Clark Medical Center | Parkersburg West Virginia, United States, 26101Princeton Community Hospital | Princeton West Virginia, United States, 24740ThedaCare Regional Cancer Center | Appleton Wisconsin, United States, 54911HSHS Sacred Heart Hospital | Eau Claire Wisconsin, United States, 54701Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire Wisconsin, United States, 54701Saint Agnes Hospital/Agnesian Cancer Center | Fond du Lac Wisconsin, United States, 54935University of Wisconsin Carbone Cancer Center - Johnson Creek | Johnson Creek Wisconsin, United States, 53038Gundersen Lutheran Medical Center | La Crosse Wisconsin, United States, 54601SSM Health Dean Medical Group - South Madison Campus | Madison Wisconsin, United States, 53715University of Wisconsin Carbone Cancer Center - University Hospital | Madison Wisconsin, United States, 53792Marshfield Medical Center-Marshfield | Marshfield Wisconsin, United States, 54449Marshfield Medical Center | Marshfield Wisconsin, United States, 54449Marshfield Medical Center - Minocqua | Minocqua Wisconsin, United States, 54548ProHealth Oconomowoc Memorial Hospital | Oconomowoc Wisconsin, United States, 53066Aspirus Cancer Care - James Beck Cancer Center | Rhinelander Wisconsin, United States, 54501Marshfield Medical Center-Rice Lake | Rice Lake Wisconsin, United States, 54868Aspirus Cancer Care - Stevens Point | Stevens Point Wisconsin, United States, 54481ProHealth Waukesha Memorial Hospital | Waukesha Wisconsin, United States, 53188Aspirus Regional Cancer Center | Wausau Wisconsin, United States, 54401Marshfield Clinic-Wausau Center | Wausau Wisconsin, United States, 54401Marshfield Medical Center - Weston | Weston Wisconsin, United States, 54476Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids Wisconsin, United States, 54494Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids Wisconsin, United States, 54494Rocky Mountain Oncology | Casper Wyoming, United States, 82609Welch Cancer Center | Sheridan Wyoming, United States, 82801Rambam Medical Center | Haifa , Israel, 31096Shaare Zedek Medical Center | Jerusalem , Israel, 91031
Investigators
Principal Investigator: Alexander K Stewart, ECOG-ACRIN Cancer Research Group