A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433

Recruitment Status
ACTIVE, NOT RECRUITING
(See Contacts and Locations)Verified March 2026 by AbbVie
Sponsor
AbbVie
Information Provided by (Responsible Party)
AbbVie
Clinicaltrials.gov Identifier
NCT03345823
Other Study ID Numbers:
M14-430
First Submitted
November 14, 2017
First Posted
November 16, 2017
Last Update Posted
April 8, 2026
Last Verified
March 2026

ClinicalTrials.gov processed this data on April 2026. Link to the current ClinicalTrials.gov record .

History of Changes

Study Details

Study Description

Condition or DiseaseIntervention/Treatment
Crohn's Disease
Drug: UpadacitinibDrug: UpadacitinibDrug: Placebo for UpadacitinibDrug: Placebo for UpadacitinibDrug: UpadacitinibDrug: UpadacitinibDrug: UpadacitinibDrug: UpadacitinibDrug: Placebo for Upadacitinib

Study Design

Study TypeInterventional
Actual Enrollment747 participants
Design AllocationRandomized
Interventional ModelSequential Assignment
MaskingQuadruple
Primary PurposeTreatment
Official TitleA Multicenter, Randomized, Double-Blind, Placebo-Controlled Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Crohn's Disease Who Completed the Studies M14-431 or M14-433
Study Start DateMarch 20, 2018
Actual Primary Completion Date1yr 3mos from now
Actual Study Completion Date1yr 3mos from now

Groups and Cohorts

Group/CohortIntervention/Treatment
Substudy 1: Cohort 1 Upadacitinib Dose A
This is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive upadacitinib dose A for 52 weeks.
Drug: Upadacitinib
Oral; Tablet
Substudy 1: Cohort 1 Upadacitinib Dose B
This is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive upadacitinib dose B for 52 weeks.
Drug: Upadacitinib
Oral; Tablet
Substudy 1: Cohort 1 Placebo
This is a maintenance group which includes participants who achieved clinical response to upadacitinib in studies M14-431 and M14-433 and will receive placebo for 52 weeks.
Drug: Placebo for Upadacitinib
Oral; Tablet
Substudy 1: Cohort 2 Placebo
This is a maintenance group which includes participants who received double-blind placebo in studies M14-431 and M14-433 and achieved clinical response will continue to receive blinded placebo for 52 Weeks.
Drug: Placebo for Upadacitinib
Oral; Tablet
Substudy 1: Cohort 3 Upadacitinib Dose B
This is a maintenance group which includes participants who achieved clinical response to upadacitinib from the extended treatment period of studies M14-431 and M14-433 and will receive upadacitinib Dose B for 52 Weeks.
Drug: Upadacitinib
Oral; Tablet
Substudy 2: Cohort 4 Upadacitinib Dose B
This is a long-term extension group which includes participants who achieved clinical response in the open-label extended treatment period of study M14-431 and will receive upadacitinib dose B for 240 weeks.
Drug: Upadacitinib
Oral; Tablet
Substudy 2: Cohort 5 Upadacitinib Dose A
This is a long-term extension group which includes participants who complete Substudy 1 and will receive upadacitinib dose A for 240 weeks.
Drug: Upadacitinib
Oral; Tablet
Substudy 2: Cohort 5 Upadacitinib Dose B
This is a long-term extension group which includes participants who complete Substudy 1 and will receive upadacitinib dose B for 240 weeks.
Drug: Upadacitinib
Oral; Tablet
Substudy 2: Cohort 5 Placebo
This is a long-term extension group which includes participants who complete Substudy 1 and will receive placebo for 240 weeks.
Drug: Placebo for Upadacitinib
Oral; Tablet

Outcome Measures

Primary Outcome Measures
  1. Sub-Study 1: Percentage of Participants with Clinical Remission per Crohn's Disease Activity Index (CDAI)
    Clinical remission per CDAI is defined as CDAI \<150.
  2. Sub-Study 1: Percentage of Participants with Endoscopic Response
    Endoscopic response is defined as decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) from Baseline.
  3. Number of Participants with Adverse Events
    An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. The investigator assessed the relationship of each event to the use of study drug as either probably related, possibly related, probably not related or not related. A serious adverse event (SAE) is an event that results in death, is life-threatening, requires or prolongs hospitalization, results in a congenital anomaly, persistent or significant disability/incapacity or is an important medical event that, based on medical judgment, may jeopardize the participant and may require medical or surgical intervention to prevent any of the outcomes listed above. For more details on adverse events please see the Adverse Event section.
Secondary Outcome Measures
  1. Sub-Study 1: Percentage of Participants with Clinical Remission per Patient-Reported Outcomes (PROs)
    Clinical remission is defined based on average daily stool frequency (SF) AND average daily abdominal pain (AP) score.
  2. Sub-Study 1: Percentage of Participants Achieving Clinical Response 100 (CR-100)
    Decrease of at least 100 points in CDAI from Baseline.
  3. Sub-Study 1: Percentage of Participants with Endoscopic Remission
    Endoscopic remission is defined per Simplified Endoscopic Score for Crohn's Disease (SES-CD).
  4. Sub-Study 1: Percentage of Participants without Corticosteroid use for Crohn's Disease Among All Participants
    This is assessed in participants not taking corticosteroids at least 90 days prior to Week 52 and achieved clinical remission per CDAI. Clinical remission is defined as CDAI \<150.
  5. Sub-Study 1: Percentage of Participants with Clinical Remission per CDAI and Endoscopic Remission
    Clinical remission per CDAI is defined as CDAI \<150. Endoscopic remission is defined per SES-CD.
  6. Sub-Study 1: Percentage of Participants with Clinical Remission per CDAI
    Clinical remission per CDAI is defined as CDAI \<150 (as measured by the percentage of participants with clinical remission at Week 52 among those with clinical remission at Week 0).
  7. Sub-Study 1: Percentage of Participants who Discontinue Corticosteroid Use for Crohn's Disease at Least 90 Days Prior to Week 52 and Achieve Clinical Remission, in Participants Taking Corticosteroids at Baseline.
    This is assessed in participants taking corticosteroids at Baseline. Clinical remission is defined based on average daily stool frequency (SF) AND average daily abdominal pain (AP) score.
  8. Sub-Study 1: Change in Inflammatory Bowel Disease Questionnaire (IBDQ)
    The IBDQ is used to assess the quality of life of patients with inflammatory bowel disease.
  9. Sub-Study 1: Change in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F)
    The FACIT-F questionnaire was developed to assess fatigue.
  10. Sub-Study 1: Percentage of Participants with Hospitalizations due to Crohn's Disease (CD)
    This is assessed by reviewing participant's hospitalization data.
  11. Sub-Study 1: Percentage of Participants with Resolution of Extra-Intestinal Manifestation (EIMs) , in Participants with EIMs at Baseline
    EIMs are defined as manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver.

Eligibility Criteria

Ages Eligible for Study(Adult, Older Adult)
Sexes Eligible for StudyAll
Accepts Healthy VolunteersNo
Inclusion Criteria
For Substudy 1:
Participant who achieve clinical response in Study M14-431 or Study M14-433.
Participant completes study procedures in the parent study. The final endoscopy for Studies M14-431 or M14-433 may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic. For Substudy 2:
Participant completes Substudy 1. The Week 52 endoscopy may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic.
Participant who achieved clinical response at the time described in the protocol and completes study procedures in the parent study/ substudy.
Exclusion Criteria
For Substudies 1 and 2:
Participant is considered by the investigator, for any reason, to be an unsuitable candidate for the study.
Participant who has a known hypersensitivity to upadacitinib or its excipients, or had an adverse event during Studies M14-431 and M14-433 or Substudy 1 or 2 of Study M14-430 that in the investigator's judgment makes the participant unsuitable for this study.
Participant at the final visit of M14-431 or M14-433 with any active or chronic recurring infections based on the investigator's assessment that makes the participant an unsuitable candidate for the study. Participants with serious infections undergoing treatment may be enrolled BUT NOT dosed until the infection treatment has been completed and the infection is resolved, based on the investigator's assessment.
Participants with high grade colonic dysplasia or malignancy diagnosed at the endoscopy performed at the final visit of Studies M14-431, M14-433 or Substudy 1 of Study M14-430 (Week 52).

Contacts and Locations

Sponsors and CollaboratorsAbbVie
Locations
East View Medical Research, LLC /ID# 171132 | Mobile Alabama, United States, 36606CB Flock Research Corporation /ID# 166239 | Mobile Alabama, United States, 36608Delsol Research Management, Ll /Id# 170164 | Chandler Arizona, United States, 85224Duplicate_HonorHealth Research Institute - Shea /ID# 164725 | Scottsdale Arizona, United States, 85258Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 164702 | Sun City Arizona, United States, 85306Southern California Res. Ctr. /ID# 169653 | Coronado California, United States, 92118-1408Citrus Valley Gastroenterology /ID# 166230 | Covina California, United States, 91722-3797Hoag Memorial Hosp Presbyterian /ID# 222538 | Irvine California, United States, 92618UC San Diego Health System /ID# 164763 | La Jolla California, United States, 92037United Medical Doctors /ID# 207458 | Los Alamitos California, United States, 90720-3309Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164640 | Los Angeles California, United States, 90067-2001Facey Medical Foundation /ID# 203138 | Mission Hills California, United States, 91345United Medical Doctors - Murrieta /ID# 164602 | Murrieta California, United States, 92563Medical Assoc Research Grp /ID# 169704 | San Diego California, United States, 92123UCSF Medical Center - Mount Zion /ID# 202372 | San Francisco California, United States, 94115Univ of California San Francis /ID# 164653 | San Francisco California, United States, 94158Care Access Research /ID# 167765 | San Pablo California, United States, 94806Peak Gastroenterology Associates, PC /ID# 170166 | Colorado Springs Colorado, United States, 80907Delta Waves, Inc. /ID# 164656 | Colorado Springs Colorado, United States, 80918Western States Clinical Res /ID# 164625 | Wheat Ridge Colorado, United States, 80033-2896Gastroenterology Center of Connecticut /ID# 164614 | Hamden Connecticut, United States, 06518Advanced Research - Coral Springs /ID# 218019 | Coral Springs Florida, United States, 33067-3173Encore Borland-Groover Clinical Research /Id# 203500 | Jacksonville Florida, United States, 32256Ctr for Advanced Gastroenterol /ID# 165306 | Maitland Florida, United States, 32751-6108Crystal Pharmacology Research /ID# 166118 | Miami Florida, United States, 33165Coral Research Clinic /ID# 164604 | Miami Florida, United States, 33186-4643Advanced Research Institute, Inc /ID# 164601 | New Port Richey Florida, United States, 34653Endoscopic Research, Inc. /ID# 206139 | Orlando Florida, United States, 32803Omega Research Group /ID# 203482 | Orlando Florida, United States, 32808Duplicate_Clinical Research of West Florida, Inc /ID# 205828 | Tampa Florida, United States, 33606-1246Duplicate_Clinical Research of West Florida, Inc /ID# 208119 | Tampa Florida, United States, 33606-1246Clinical Research Trials of Florida, Inc. /ID# 203486 | Tampa Florida, United States, 33607Duplicate_AdventHealth Tampa /ID# 171181 | Tampa Florida, United States, 33613-4680Gastroenterology Associates of Central Georgia, LLC /ID# 165492 | Macon Georgia, United States, 31201Gastroenterology Consultants, P.C /ID# 218218 | Roswell Georgia, United States, 30076-4913Atlanta Gastroenterology Spec /ID# 164698 | Suwanee Georgia, United States, 30024Treasure Valley Medical Research /ID# 215030 | Boise Idaho, United States, 83706Duplicate_Rush University Medical Center /ID# 165470 | Chicago Illinois, United States, 60612Duplicate_University of Chicago Medicine /ID# 165509 | Chicago Illinois, United States, 60637-1426DuPage Medical Group /ID# 205320 | Downers Grove Illinois, United States, 60515-5509MediSphere Medical Research Center /ID# 166233 | Evansville Indiana, United States, 47714-8011Indianapolis Gastroenterology /ID# 164649 | Indianapolis Indiana, United States, 46237Aquiant Research /ID# 205505 | New Albany Indiana, United States, 47150-4053University of Iowa Hospitals and Clinics /ID# 165405 | Iowa City Iowa, United States, 52242Tri-State Gastroenterology /ID# 165469 | Crestview Hills Kentucky, United States, 41017Duplicate_University of Louisville /ID# 165391 | Louisville Kentucky, United States, 40202University of Louisville Hospital /ID# 168520 | Louisville Kentucky, United States, 40202Houma Digestive Health Special /ID# 164727 | Houma Louisiana, United States, 70360Nola Research Works, LLC /ID# 164612 | New Orleans Louisiana, United States, 70115Louisiana Research Center, LLC /ID# 164694 | Shreveport Louisiana, United States, 71105-6800Duplicate_Johns Hopkins University School of Medicine /ID# 211939 | Baltimore Maryland, United States, 21287-0010Metropolitan Gastroenterology Group - Chevy Chase /ID# 164647 | Chevy Chase Maryland, United States, 20815Gastro Center of Maryland /ID# 171180 | Columbia Maryland, United States, 21045Duplicate_Lahey Hospital and Medical Center /ID# 214724 | Burlington Massachusetts, United States, 01805University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164654 | Ann Arbor Michigan, United States, 48109Clin Res Inst of Michigan, LLC /ID# 170163 | Chesterfield Michigan, United States, 48047Digestive Health Associates (DHA) - Farmington Hills /ID# 206101 | Farmington Hills Michigan, United States, 48334-3230Center for Digestive Health /ID# 164726 | Troy Michigan, United States, 48098-6363Mayo Clinic - Rochester /ID# 164691 | Rochester Minnesota, United States, 55905-0001Southern Therapy and Advanced Research (STAR) LLC /ID# 165295 | Jackson Mississippi, United States, 39216Quality Clinical Research Inc. /ID# 170162 | Omaha Nebraska, United States, 68114-3723CHI Health Research Center /ID# 168513 | Omaha Nebraska, United States, 68124Las Vegas Medical Research /ID# 168551 | Las Vegas Nevada, United States, 89113Cooper Gastroenterology at Fire Road /ID# 164641 | Egg Harbor New Jersey, United States, 08234Rutgers Robert Wood Johnson /ID# 166110 | New Brunswick New Jersey, United States, 08901NY Scientific /ID# 164630 | Brooklyn New York, United States, 11235United Health Services Hospitals, Inc /ID# 217483 | Johnson City New York, United States, 13790-2107NYU Langone Long Island Clinical Research Associates /ID# 164627 | Lake Success New York, United States, 11042The Mount Sinai Hospital /ID# 170256 | New York New York, United States, 10029Columbia Univ Medical Center /ID# 164692 | New York New York, United States, 10032-3725Gastoenterology Group of Rochester /ID# 166235 | Rochester New York, United States, 14618-5703Richmond University Medical Center /ID# 201858 | Staten Island New York, United States, 10310-1664Montefiore Medical Center - Moses Campus /ID# 166242 | The Bronx New York, United States, 10467Advantage Clinical Trials /ID# 168582 | The Bronx New York, United States, 10468Atrium Health Carolinas Medical Center /ID# 164632 | Charlotte North Carolina, United States, 28203Duplicate_PMG Research of Charlotte /ID# 171178 | Charlotte North Carolina, United States, 28209Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164752 | Raleigh North Carolina, United States, 27612Duplicate_Atrium Health Wake Forest Baptist Medical Center /ID# 164755 | Winston-Salem North Carolina, United States, 27157-0001Plains Clinical Research Center, LLC /ID# 170169 | Fargo North Dakota, United States, 58104-5925Gastro Health Research /ID# 164668 | Cincinnati Ohio, United States, 45219Duplicate_Duplicate_University Of Cincinnati Medical Center /ID# 164729 | Cincinnati Ohio, United States, 45267-0585Cleveland Clinic Main Campus /ID# 209230 | Cleveland Ohio, United States, 44195Ohio State University/ Gastroe /ID# 170159 | Columbus Ohio, United States, 43210Optimed Research, Ltd. /ID# 205625 | Columbus Ohio, United States, 43235Hometown Urgent Care and Resea /ID# 201289 | Dayton Ohio, United States, 45424Dayton Gastroenterology, Inc. /ID# 167623 | Englewood Ohio, United States, 45415Great Lakes Gastroenterology Research, LLC /ID# 202006 | Mentor Ohio, United States, 44060-6211Digestive Disease Specialists /ID# 201063 | Oklahoma City Oklahoma, United States, 73112Options Health Research, LLC /ID# 164704 | Tulsa Oklahoma, United States, 74104Healthcare Research Consultant /ID# 166244 | Tulsa Oklahoma, United States, 74135University of Pennsylvania /ID# 168406 | Philadelphia Pennsylvania, United States, 19104-5502Duplicate_Thomas Jefferson University /ID# 168003 | Philadelphia Pennsylvania, United States, 19107-4414Pharmacorp Clinical Trials /ID# 165008 | Charleston South Carolina, United States, 29412Gastroenterology Associates, P.A. of Greenville /ID# 164643 | Greenville South Carolina, United States, 29607Rapid City Medical Center - GI Research /ID# 201733 | Rapid City South Dakota, United States, 57701Gastro One /ID# 164730 | Cordova Tennessee, United States, 38018Duplicate_East Tennessee Research Institute /ID# 203614 | Johnson City Tennessee, United States, 37604Quality Medical Research /ID# 205264 | Nashville Tennessee, United States, 37211Vanderbilt University Medical Center /ID# 164607 | Nashville Tennessee, United States, 37232-0011TX Clinical Research Institute /ID# 164719 | Arlington Texas, United States, 76012Inquest Clinical Research /ID# 164676 | Baytown Texas, United States, 77521-2415GI Alliance /ID# 209803 | Cedar Park Texas, United States, 78613Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170161 | Dallas Texas, United States, 75246Baylor College of Medicine /ID# 164609 | Houston Texas, United States, 77030Centex Studies, Inc. - Houston /ID# 201212 | Houston Texas, United States, 77058GI Specialists of Houston /ID# 202340 | Houston Texas, United States, 77070-4347Caprock Gastro Research - Lubbock - 80th Street /ID# 215436 | Lubbock Texas, United States, 79424Clinical Associates in Research Therapeutics of America, LLC /ID# 164675 | San Antonio Texas, United States, 78212Southern Star Research Institute, LLC /ID# 169756 | San Antonio Texas, United States, 78229-5390Carl R. Meisner Medical Clinic /ID# 171057 | Sugar Land Texas, United States, 77478Tyler Research Institute, LLC /ID# 168679 | Tyler Texas, United States, 75701Gastro Health & Nutrition - Victoria /ID# 167810 | Victoria Texas, United States, 77904Texas Digestive Disease Consultants /ID# 209954 | Webster Texas, United States, 77598HP Clinical Research /ID# 164631 | Bountiful Utah, United States, 84010Advanced Research Institute /ID# 164689 | Ogden Utah, United States, 84405Duplicate_Care Access Research /ID# 164685 | Salt Lake City Utah, United States, 84124-1377Duplicate_Velocity Clinical Research - Salt Lake City /ID# 166113 | West Jordan Utah, United States, 84088Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 164728 | Bellevue Washington, United States, 98004Virginia Mason Hospital & Medical Center /ID# 164862 | Seattle Washington, United States, 98101University of Washington /ID# 164646 | Seattle Washington, United States, 98109The Vancouver Clinic, INC. PS /ID# 164874 | Vancouver Washington, United States, 98664Froedtert Memorial Lutheran Hospital /ID# 202285 | Milwaukee Wisconsin, United States, 53226-3522Allegiance Research Specialists /ID# 165298 | Wauwatosa Wisconsin, United States, 53226Cemic /Id# 169183 | Ciudad Autonoma Buenos Aires Buenos Aires, Argentina, 1431Cardio Alem /ID# 211283 | San Isidro Buenos Aires, Argentina, 1642Hospital Italiano de Buenos Aires /ID# 215542 | Ciudad Autonoma Buenos Aires Buenos Aires F.D., Argentina, 1199Gedyt /ID# 210018 | Ciudad Autonoma de Buenos Aire Buenos Aires F.D., Argentina, 1115Hospital Provincial del Centenario /ID# 171251 | Rosario Santa Fe Province, Argentina, 2000Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 169229 | Córdoba , Argentina, 5016Concord Repatriation General Hospital /ID# 171506 | Concord New South Wales, Australia, 2139Coral Sea Clinical Research institute /ID# 212989 | North Mackay Queensland, Australia, 4740Mater Misericordiae Limited /ID# 204910 | South Brisbane Queensland, Australia, 4101Royal Adelaide Hospital /ID# 171508 | Adelaide South Australia, Australia, 5000Box Hill Hospital /ID# 203735 | Box Hill Victoria, Australia, 3128Fiona Stanley Hospital /ID# 171507 | Murdoch Western Australia, Australia, 6150Klinik Landstrasse /ID# 203438 | Vienna State of Vienna, Austria, 1030Medizinische Universitaet Wien /ID# 169459 | Vienna State of Vienna, Austria, 1090Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 214468 | Salzburg , Austria, 5020Cliniques Universitaires UCL Saint-Luc /ID# 200293 | Brussels Brussels Capital, Belgium, 1200Universite Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 200295 | Yvoir Namur, Belgium, 5530Duplicate_AZ Sint-Lucas /ID# 200296 | Ghent Oost-Vlaanderen, Belgium, 9000Universitair Ziekenhuis Leuven /ID# 200031 | Leuven Vlaams-Brabant, Belgium, 3000CHU de Liege /ID# 200294 | Liège , Belgium, 4000Duplicate_University Clinical Centre of the Republic of Srpska /ID# 200743 | Banja Luka Republika Srpska, Bosnia and Herzegovina, 78000University Clinical Center Tuzla /ID# 210323 | Tuzla Tuzlanski, Bosnia and Herzegovina, 75000Clinical Center University of Sarajevo /ID# 201346 | Sarajevo , Bosnia and Herzegovina, 71000Polyclinic and Daily Hospital Dr. Al-Tawil /ID# 217843 | Sarajevo , Bosnia and Herzegovina, 71000Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 166853 | Goiânia Goiás, Brazil, 74535-170Faculdade de Medicina do ABC /ID# 166854 | Santo André La Spezia, Brazil, 09060-870Hospital Nossa Senhora das Graças /ID# 166856 | Curitiba Paraná, Brazil, 80810-040Hospital de Clinicas de Porto Alegre /ID# 166855 | Porto Alegre Rio Grande do Sul, Brazil, 90035-903Upeclin Fmb - Unesp /Id# 166860 | Botucatu São Paulo, Brazil, 18618-686Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 166859 | Ribeirão Preto São Paulo, Brazil, 14049-900Kaiser Clinica e Hospital Dia /ID# 166858 | São José do Rio Preto São Paulo, Brazil, 15015-110Duplicate_UMHAT Kaspela EOOD /ID# 167615 | Plovdiv , Bulgaria, 4001Duplicate_Second MHAT Sofia /ID# 167616 | Sofia , Bulgaria, 1202MHAT Trakia /ID# 201677 | Stara Zagora , Bulgaria, 6004University of Calgary /ID# 166990 | Calgary Alberta, Canada, T2N 4Z6Allen Whey Khye Lim Professional Corporation /ID# 168047 | Edmonton Alberta, Canada, T5R 1W2University of Alberta Hospital /ID# 166987 | Edmonton Alberta, Canada, T6G 2B7Covenant Health /ID# 166996 | Edmonton Alberta, Canada, T6K 4B2Fraser Clinical Trials Inc /ID# 166984 | New Westminster British Columbia, Canada, V3L 3W4Giri Gi Research Institute - Vancouver /ID# 166994 | Vancouver British Columbia, Canada, V5Z 2K5QEII - Health Sciences Centre /ID# 169308 | Halifax Nova Scotia, Canada, B3H 2Y9Medicor Research Inc /ID# 166997 | Greater Sudbury Ontario, Canada, P3A 1W8London Health Sciences Center- University Hospital /ID# 221039 | London Ontario, Canada, N6A 5W9Scott Shulman Medicine Professional Corporation /ID# 169065 | North Bay Ontario, Canada, P1B 2H3Taunton surgical centre /ID# 168045 | Oshawa Ontario, Canada, L1H 7K4Ottawa Hospital Research Institute /ID# 212412 | Ottawa Ontario, Canada, K1H 8L6Toronto Digestive Disease Associates /ID# 166988 | Vaughan Ontario, Canada, L4L 4Y7Hotel Dieu de Levis /ID# 166985 | Lévis Quebec, Canada, G6V 3Z1Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 170122 | Montreal Quebec, Canada, H2X 0A9Disc_Royal Victoria Hospital / McGill University Health Centre /ID# 170011 | Montreal Quebec, Canada, H4A 3J1CIUSSS de l'Estrie - CHUS /ID# 170936 | Sherbrooke Quebec, Canada, J1G 2E8Hospital Guillermo Grant Benavente de Concepción /ID# 212421 | Concepción Biobio, Chile, 4070038CTR Estudios Clinicos /ID# 203940 | Providencia Region Metropolitana Santiago, Chile, 7500571Research Group /ID# 203178 | Santiago Santiago Metropolitan, Chile, 2540364CEC SpA /ID# 169872 | Ñuñoa , Chile, 7750495Hospital Clinico Universidad De Los Andes /ID# 207463 | Santiago , Chile, 7501504Beijing Friendship Hospital /ID# 204175 | Beijing Beijing Municipality, China, 100032Zhongshan Hospital Xiamen University /ID# 204986 | Xiamen Fujian, China, 361004The First Affiliated Hospital, Sun Yat-sen University /ID# 205227 | Guangzhou Guangdong, China, 510080Nanfang Hospital of Southern Medical University /ID# 204056 | Guangzhou Guangdong, China, 510515The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 204054 | Guangzhou Guangdong, China, 510655Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 204065 | Wuhan Hubei, China, 430022Tongji Hospital Tongji Medical College of HUST /ID# 204051 | Wuhan Hubei, China, 430030The Second Xiangya Hospital Of Central South University /ID# 204057 | Changsha Hunan, China, 410011Nanjing Drum Tower Hospital /ID# 204899 | Nanjing Jiangsu, China, 210008The First Affiliated Hospital of Nanchang University /ID# 204052 | Nanchang Jiangxi, China, 330006The First Hospital of Jilin University /ID# 206865 | Changchun Jilin, China, 130021Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 204055 | Shanghai Shanghai Municipality, China, 200065The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 204058 | Hangzhou Zhejiang, China, 310009Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 204050 | Hangzhou Zhejiang, China, 310018Duplicate_Tianjin Med Univ General Hosp /ID# 206979 | Tianjin , China, 300052Duplicate_Hospital Pablo Tobon Uribe /ID# 202403 | Medellín Antioquia, Colombia, 50034Hospital San Vicente de Paul /ID# 200020 | Medellín Antioquia, Colombia, 50034Clinical Hospital Dubrava /ID# 171165 | Zagreb City of Zagreb, Croatia, 10000Klinicki bolnicki centar Sestre milosrdnice /ID# 171194 | Zagreb City of Zagreb, Croatia, 10000Klinicki bolnicki centar Zagreb /ID# 171168 | Zagreb City of Zagreb, Croatia, 10000Poliklinika Solmed /ID# 211517 | Zagreb City of Zagreb, Croatia, 10000Klinicki Bolnicki Centar KBC Split /ID# 171205 | Split Split-Dalmatia County, Croatia, 21000Zadar General Hospital /ID# 205533 | Zadar , Croatia, 23000Nemocnice Ceske Budejovice a.s. /ID# 224390 | České Budějovice , Czechia, 370 01Hepato-Gastroenterologie HK, s.r.o. /ID# 171564 | Hradec Králové , Czechia, 500 12ARTROSCAN s.r.o. /ID# 171575 | Ostrava , Czechia, 722 00ResTrial s.r.o. /ID# 208651 | Prague , Czechia, 143 00Herlev Hospital /ID# 200785 | Herlev Capital Region, Denmark, 2730Nordsjaellands Hospital /ID# 200788 | Hilleroed Capital Region, Denmark, 3600Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 200787 | Hvidovre Capital Region, Denmark, 2650Duplicate_Sjaellands Universitets Hospital /ID# 200786 | Roskilde Region Sjælland, Denmark, 4000Alexandria University /ID# 171008 | Alexandria Alexandria Governorate, Egypt, 21131Alexandria University /ID# 171017 | Alexandria Alexandria Governorate, Egypt, 21131National Liver Institute /ID# 170987 | Menoufiya Monufia Governorate, Egypt, 35111Duplicate_Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 209561 | Alexandria , Egypt, 21131National Hepatology and Tropical Medicine Research Institute /ID# 170991 | Cairo , Egypt, 11559Ain Shams University Faculty of Medicine /ID# 209566 | Cairo , Egypt, 11566Air Force Specialized Hospital /ID# 170993 | Cairo , Egypt, West Tallinn Central Hospital /ID# 202787 | Tallinn Harju, Estonia, 10617Tartu University Hospital /ID# 203141 | Tartu , Estonia, 50406Chu de Nice-Hopital Larchet Ii /Id# 171004 | Nice Alpes-Maritimes, France, 06202Duplicate_CHU Bordeaux - Hopital Haut Leveque /ID# 207812 | Pessac Gironde, France, 33604CHU Toulouse - Hopital Rangueil /ID# 169784 | Toulouse Haute-Garonne, France, 31400Duplicate_Hopital Saint Eloi /ID# 170039 | Montpellier Herault, France, 34295Duplicate_CHU Grenoble - Hopital Michallon /ID# 222403 | La Tronche Isere, France, 38700Duplicate_CHRU Nancy - Hopitaux de Brabois /ID# 170970 | Vandœuvre-lès-Nancy Meurthe-et-Moselle, France, 54500CHRU Lille - Hopital Claude Huriez /ID# 206653 | Lille Nord, France, 59037CH Valenciennes /ID# 222399 | Valenciennes Nord, France, 59300Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 171027 | St-Priest-en-Jarez Pays de la Loire Region, France, 42270HCL - Hopital Lyon Sud /ID# 171030 | Pierre-Bénite Rhone, France, 69495Duplicate_CHU Amiens-Picardie Site Sud /ID# 171023 | Amiens Somme, France, 80054CHRU Tours - Hopital Trousseau /ID# 169783 | Chambray-lès-Tours , France, 37170Duplicate_CHU Henri Mondor /ID# 169782 | Créteil , France, 94000Clinique Jules Verne /ID# 222240 | Nantes , France, 44300Polyclinique Grand Sud /ID# 170037 | Nîmes , France, 30932Hopital Beaujon /ID# 171007 | Clichy Île-de-France Region, France, 92110Universitatsklinikum Mannheim /ID# 168754 | Mannheim Baden-Wurttemberg, Germany, 68167Universitaetsklinikum Ulm /ID# 203554 | Ulm Baden-Wurttemberg, Germany, 89081Universitaetsklinikum Erlangen /ID# 203550 | Erlangen Bavaria, Germany, 91054Duplicate_Agaplesion Markus Krankenhaus /ID# 168753 | Frankfurt am Main Hesse, Germany, 60431Universitaetsklinikum Frankfurt /ID# 203567 | Frankfurt am Main Hesse, Germany, 60590Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 206739 | Saarbrücken Saarland, Germany, 66111Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 168755 | Kiel Schleswig-Holstein, Germany, 24105Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 169271 | Berlin , Germany, 12203Gastroenterologie am Mexikoplatz /ID# 203574 | Berlin , Germany, 14163Universitaetsmedizin Essen St. Josef Krankenhaus Werden /ID# 203569 | Essen , Germany, 45239Universitaetsklinikum Halle (Saale) /ID# 207453 | Halle , Germany, 06120Medizinisches Versorgungszentrum Portal 10 /ID# 200212 | Münster , Germany, 48155General Hospital of Athens Ippokratio /ID# 167032 | Athens Attica, Greece, 11527General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202102 | Athens Attica, Greece, 11527Tzaneio general hospital of Piraeus /ID# 206435 | Piraeus Attica, Greece, 18536University General Hospital of Heraklion PA.G.N.I /ID# 167031 | Heraklion Crete, Greece, 71500General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 167033 | Athens , Greece, 10676General Hospital of Thessaloniki Hippokrateio /ID# 208823 | Thessaloniki , Greece, 54642Queen Mary Hospital /ID# 171214 | Hong Kong , Hong Kong, 999077Tuen Mun Hospital /ID# 171213 | Hong Kong , Hong Kong, Pecsi Tudomanyegyetem Klinikai Kozpont Mohacsi Korhaz /ID# 209440 | Mohács Baranya, Hungary, 7700CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 205549 | Encs Borsod-Abauj Zemplen county, Hungary, 3860Duplicate_Debreceni Egyetem Klinikai Kozpont /ID# 216420 | Debrecen Hajdú-Bihar, Hungary, 4032Gyongyosi Bugat Pal Korhaz /ID# 201885 | Gyöngyös Heves County, Hungary, 3200Komarom-Esztergom Varmegyei Szent Borbala Korhaz (Clinexpert Tatabanya Kft.) /ID# 209896 | Tatabánya Komárom-Esztergom, Hungary, 2800Kistarcsai Flor Ferenc Korhaz /ID# 206153 | Kistarcsa Pest County, Hungary, 2143Obudai Egeszsegugyi Centrum /ID# 201886 | Budapest , Hungary, 1036Duplicate_Semmelweis Egyetem /ID# 210166 | Budapest , Hungary, 1085Magyar Honvedseg Egeszsegugyi Kozpont /ID# 200888 | Budapest , Hungary, 1134Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 200887 | Debrecen , Hungary, 4031Mentahaz Maganorvosi Kozpont /ID# 201888 | Székesfehérvár , Hungary, 8000Mercy University Hospital /ID# 206512 | Cork , Ireland, T12 WE28Duplicate_Kaplan Medical Center /ID# 170275 | Rehovot Central District, Israel, 7661041Yitzhak Shamir Medical Center /ID# 206449 | Ẕerifin Central District, Israel, 70300Hadassah Medical Center-Hebrew University /ID# 169926 | Jerusalem Jerusalem, Israel, 91120Barzilai Medical Center /ID# 223374 | Ashkelon Southern District, Israel, 7830604Soroka University Medical Center /ID# 169911 | Beersheba Southern District, Israel, 8443901Tel Aviv Sourasky Medical Center /ID# 206450 | Tel Aviv Tel Aviv, Israel, 6423906Rabin Medical Center. /ID# 202634 | Petah Tikva , Israel, 4941492Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 168155 | Bologna Emilia-Romagna, Italy, 40138IRCCS Istituto Clinico Humanitas /ID# 168153 | Rozzano Lombardy, Italy, 20089ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 168149 | Milan Milano, Italy, 20122ASST Grande Ospedale Metropolitano Niguarda /ID# 170906 | Milan Milano, Italy, 20162Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 168156 | Rome Roma, Italy, 00133Duplicate_Azienda Ospedaliera San Camillo Forlanini /ID# 168152 | Rome Roma, Italy, 00152Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 168150 | Rome Roma, Italy, 00168Duplicate_IRCCS Ospedale Sacro Cuore Don Calabria /ID# 168154 | Negrar Verona, Italy, 37024Ospedale Cannizzaro /ID# 168161 | Catania , Italy, 95126Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 201986 | Catanzaro , Italy, 88100Policlinico San Martino/Univer /ID# 168162 | Genova , Italy, 16132Azienda Ospedaliero-Universitaria di Modena /ID# 200009 | Modena , Italy, 41124Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 168157 | Palermo , Italy, 90146Duplicate_Azienda Ospedaliero Universitaria Pisana-Stabilimento di Cisanello /ID# 202419 | Pisa , Italy, 56125Fondazione Policlinico Universitario Campus Bio-Medico /ID# 168151 | Roma , Italy, 00128Aichi Medical University Hospital /ID# 165989 | Nagakute Aichi-ken, Japan, 480-1195Nagoya University Hospital /ID# 165987 | Nagoya Aichi-ken, Japan, 466-8560Nagoya City University Hospital /ID# 165988 | Nagoya Aichi-ken, Japan, 467-8602Toyohashi Municipal Hospital /ID# 200176 | Toyohashi Aichi-ken, Japan, 441-8570National Hospital Organization Hirosaki General Medical Center /ID# 165976 | Hirosaki-shi Aomori, Japan, 036-8545Toho University Sakura Medical Center /ID# 165978 | Sakura-shi Chiba, Japan, 285-8741Fukuoka University Chikushi Hospital /ID# 214402 | Chikushino-shi Fukuoka, Japan, 818-8502Kurume University Hospital /ID# 165996 | Kurume-shi Fukuoka, Japan, 830-0011National Hospital Organization Takasaki General Medical Center /ID# 167151 | Takasaki-shi Gunma, Japan, 370-0829Duplicate_NHO Fukuyama Medical Center /ID# 167155 | Fukuyama-shi Hiroshima, Japan, 720-8520Hiroshima University Hospital /ID# 165998 | Hiroshima Hiroshima, Japan, 734-8551Duplicate_Asahikawa Medical University Hospital /ID# 167148 | Asahikawa-shi Hokkaido, Japan, 078-8510Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 165975 | Sapporo Hokkaido, Japan, 060-0033Duplicate_Sapporo Medical University Hospital /ID# 167152 | Sapporo Hokkaido, Japan, 060-8543Sapporo IBD Clinic /ID# 223559 | Sapporo Hokkaido, Japan, 064-0919Aoyama Clinic /ID# 165993 | Kobe Hyōgo, Japan, 650-0015Duplicate_Hyogo Medical University Hospital /ID# 165991 | Nishinomiya-shi Hyōgo, Japan, 663-8501Kanazawa University Hospital /ID# 169212 | Kanazawa Ishikawa-ken, Japan, 920-8641Iwate Medical University Uchimaru Medical Center /ID# 202465 | Morioka Iwate, Japan, 020-8505Imamura General Hospital /ID# 227135 | Kagoshima Kagoshima-ken, Japan, 890-0064Idzuro Imamura Hospital /ID# 206655 | Kagoshima Kagoshima-ken, Japan, 892-0824Sameshima Hospital /ID# 206677 | Kagoshima Kagoshima-ken, Japan, 892-0846Duplicate_Yokohama City University Medical Center /ID# 167156 | Yokohama Kanagawa, Japan, 232-0024Japanese Red Cross Kyoto Daiichi Hosital /ID# 165990 | Kyoto Kyoto, Japan, 605-0981Duplicate_Kyoto University Hospital /ID# 169887 | Kyoto Kyoto, Japan, 606-8507Yokkaichi Hazu Medical Center /ID# 167201 | Yokkaichi-shi Mie-ken, Japan, 510-0016Tohoku University Hospital /ID# 167150 | Sendai Miyagi, Japan, 9808574Nara Medical University Hospital /ID# 169213 | Kashihara-shi Nara, Japan, 634-8522Kenseikai Dongo Hospital /ID# 208105 | Yamatotakada-shi Nara, Japan, 635-0022Duplicate_Niigata University Medical & Dental Hospital /ID# 170042 | Niigata Niigata, Japan, 951-8520Ishida Clinic of IBD and Gastroenterology /ID# 167149 | Ōita Oita Prefecture, Japan, 870-0823Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 165994 | Kurashiki-shi Okayama-ken, Japan, 710-0142Duplicate_Okayama University Hospital /ID# 167354 | Okayama Okayama-ken, Japan, 700-8558Kinshukai Infusion Clinic /ID# 218873 | Osaka Osaka, Japan, 530-0011Osaka Metropolitan University Hospital /ID# 165999 | Osaka Osaka, Japan, 545-8586Duplicate_Osaka University Hospital /ID# 169661 | Suita-shi Osaka, Japan, 565-0871Osaka Medical and Pharmaceutical University Hospital /ID# 206323 | Takatsuki-shi Osaka, Japan, 569-8686Tokitokai Tokito clinic /ID# 165977 | Saitama-shi Saitama, Japan, 336-0963Duplicate_Shiga University of Medical Science Hospital /ID# 167157 | Ōtsu Shiga, Japan, 520-2192Duplicate_Hamamatsu University Hospital /ID# 224402 | Hamamatsu Shizuoka, Japan, 431-3192Duplicate_NHO Shizuoka Medical Center /ID# 167153 | Sunto-gun Shizuoka, Japan, 411-8611Institute of Science Tokyo Hospital /ID# 165982 | Bunkyo-ku Tokyo, Japan, 113-8519Tokai University Hachioji Hospital /ID# 165984 | Hachioji-shi Tokyo, Japan, 192-0032Duplicate_The Jikei University Hospital /ID# 167154 | Minato-ku Tokyo, Japan, 105-8471Kyorin University Hospital /ID# 165983 | Mitaka-shi Tokyo, Japan, 181-8611Duplicate_Tokyo Women's Medical University Hospital /ID# 205979 | Shinjuku-ku Tokyo, Japan, 162-8666Toyama Prefectural Central Hospital /ID# 217836 | Toyama Toyama, Japan, 930-8550Japanese Red Cross Wakayama Medical Center /ID# 200641 | Wakayama Wakayama, Japan, 640-8558Wakayama Medical University Hospital /ID# 169480 | Wakayama Wakayama, Japan, 641-8510Yamagata University Hospital /ID# 200158 | Yamagata Yamagata, Japan, 990-9585VCA Polyclinic Aura /ID# 169499 | Riga , Latvia, 1035Pauls Stradins Clinical University Hospital /ID# 169494 | Riga , Latvia, LV-1002Duplicate_Digestive Disease Center Gastro /ID# 169518 | Riga , Latvia, LV-1079Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 207030 | Kaunas , Lithuania, 50161Vilnius University Hospital Santaros Klinikos /ID# 203269 | Vilnius , Lithuania, 08661Duplicate_Hospital Sultanah Bahiyah /ID# 201317 | Alor Star Kedah, Malaysia, 05460Universiti Sains Malaysia /ID# 200101 | Kelantan Kelantan, Malaysia, 16150Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 170780 | Kuala Lumpur Selangor, Malaysia, 56000Instituto de Investigaciones Aplicadas a la Neurociencias A.C. /ID# 207681 | Durango Durango, Mexico, 34000Morales Vargas Centro de Investigacion S.C. /ID# 203496 | León Guanajuato, Mexico, 37000Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 206843 | Guadalajara Jalisco, Mexico, 44650Radboud Universitair Medisch Centrum /ID# 166931 | Nijmegen Gelderland, Netherlands, 6525 GAZuyderland Medisch Centrum /ID# 169699 | Heerlen Limburg, Netherlands, 6419 PCAmsterdam UMC, Location VUmc /ID# 166930 | Amsterdam North Holland, Netherlands, 1081 HVOlvg /Id# 166932 | Amsterdam North Holland, Netherlands, 1091 ACMedisch Spectrum Twente /ID# 170299 | Enschede Overijssel, Netherlands, 7512 KZMalopolskie Centrum Kliniczne /ID# 202169 | Krakow Lesser Poland Voivodeship, Poland, 30-149Vistamed /ID# 208571 | Wroclaw Lower Silesian Voivodeship, Poland, 53-149Centrum Zdrowia MDM /ID# 200493 | Warsaw Masovian Voivodeship, Poland, 00-189Duplicate_WIP Warsaw IBD Point Profesor Kierkus /ID# 224302 | Warsaw Masovian Voivodeship, Poland, 00-728Centrum Medyczne Reuma Park /ID# 200489 | Warsaw Masovian Voivodeship, Poland, 02-665Duplicate_Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 170204 | Guimarães Braga District, Portugal, 4835-044Hospital Egas Moniz /ID# 170232 | Lisbon Porto District, Portugal, 1349-019Duplicate_Hospital Garcia de Orta, EPE /ID# 170209 | Almada Setúbal District, Portugal, 2805-267Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 200608 | Ponte de Lima Viana do Castelo District, Portugal, 4990-041Unidade Local de Saude Sao Joao, EPE /ID# 170211 | Porto , Portugal, 4200-319Mindful Medical Research /ID# 203356 | San Juan , Puerto Rico, 00918-3756School of Medicine University of Puerto Rico-Medical Science Campus /ID# 166769 | San Juan , Puerto Rico, 00935Fundeni Clinical Institute /ID# 167831 | Bucharest Bucharest, Romania, 022328Duplicate_Clinica GASTRO MED SRL /ID# 206363 | Cluj-Napoca Cluj, Romania, 400380Cabinet Particular Policlinic Algomed /ID# 167832 | Timișoara , Romania, 300002Immanuel Kant Baltic Federal University /ID# 203810 | Kaliningrad Kaliningrad Oblast, Russia, 236016Republican hospital named after V.A. Baranov /ID# 206497 | Petrozavodsk Murmansk Oblast, Russia, 185019LLC Medical Center /ID# 209234 | Novosibirsk Novosibirsk Oblast, Russia, 630099Perm Clinical Center of the Federal Medical and Biological Agency /ID# 202989 | Perm Permskiy Kray, Russia, 614109LLC Novaya Klinika /ID# 206613 | Pyatigorsk Stavropol Kray, Russia, 357500Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 202996 | Stavropol Stavropol Kray, Russia, 355012Kazan State Medical University /ID# 169589 | Kazan' Tatarstan, Respublika, Russia, 420012Olla-Med Clinic /ID# 208723 | Moscow , Russia, 105554P.A. Bayandin Murmansk Regiona /ID# 169590 | Murmansk , Russia, 183047Euromedservice /ID# 206608 | Pushkin , Russia, 196603X7 Clinical Research Center /ID# 216348 | Saint Petersburg , Russia, 194156City Clinical Hospital No. 31 /ID# 208871 | Saint Petersburg , Russia, 197110Clinical Hosp Center Zvezdara /ID# 168216 | Belgrade Beograd, Serbia, 11000Military Medical Academy /ID# 168785 | Belgrade Beograd, Serbia, 11000University Clinical Center Serbia /ID# 168217 | Belgrade Beograd, Serbia, 11000Clin Hosp Ctr Bezanijska Kosa /ID# 168787 | Belgrade Beograd, Serbia, 11080Duplicate_University Clinical Center Kragujevac /ID# 205856 | Kragujevac Sumadijski Okrug, Serbia, 34000Duplicate_Clinical Center Vojvodina /ID# 168196 | Novi Sad Vojvodina, Serbia, 21000Duplicate_KL Ling Gastroenterology and Liver Clinic /ID# 205739 | Singapore Central Singapore, Singapore, 228510Gleneagles Medical Centre /ID# 206019 | Singapore , Singapore, 258499Tan Tock Seng Hospital /ID# 203158 | Singapore , Singapore, 308433Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 169960 | Banská Bystrica Banská Bystrica Region, Slovakia, 975 17KM Management, spol. s.r.o. /ID# 170202 | Nitra Nitra Region, Slovakia, 949 01Univ Medical Ctr Ljubljana /ID# 211041 | Ljubljana , Slovenia, 1000Farmovs (Pty) Ltd /Id# 207534 | Bloemfontein Free State, South Africa, 9301Lenasia Clinical Trial Centre /ID# 205143 | Johannesburg Gauteng, South Africa, 1820Wits Clinical Research /ID# 170850 | Johannesburg Gauteng, South Africa, 1864Allergy & Immunology (AIU) /ID# 171427 | Cape Town Western Cape, South Africa, 7700Dr JP Wright /ID# 170882 | Cape Town Western Cape, South Africa, 7708Private Practice Dr MN Rajabally /ID# 169851 | Cape Town Western Cape, South Africa, 7800Inje University Haeundae Hospital /ID# 202631 | Busan Busan Gwang Yeogsi, South Korea, 48108Dong-A University Medical Center /ID# 167568 | Busan Busan Gwang Yeogsi, South Korea, 49201Duplicate_Pusan National University Hospital /ID# 167565 | Busan Busan Gwang Yeogsi, South Korea, 49241Kyungpook National University Hospital /ID# 207020 | Daegu Daegu Gwang Yeogsi, South Korea, 41944Duplicate_Hanyang University Gurihospital /ID# 167563 | Guri-si Gyeonggido, South Korea, 11923Duplicate_CHA University Bundang Medical Center /ID# 167569 | Seongnam-si Gyeonggido, South Korea, 13496Chungang University Hospital /ID# 207021 | Dongjak-gu Seoul Teugbyeolsi, South Korea, 06973Kangbuk Samsung Hospital /ID# 167562 | Seoul Seoul Teugbyeolsi, South Korea, 03181Samsung Medical Center /ID# 167564 | Seoul Seoul Teugbyeolsi, South Korea, 06351Yonsei University Health System Severance Hospital /ID# 167567 | Seoul , South Korea, 03722Hospital Universitari Son Espases /ID# 201969 | Palma de Mallorca Balearic Islands, Spain, 07120Hospital Universitario Marques de Valdecilla /ID# 202495 | Santander Cantabria, Spain, 39008Hospital Universitario Dr. Negrin /ID# 202723 | Las Palmas de Gran Canaria Las Palmas, Spain, 35019Hospital Universitario de Navarra /ID# 202354 | Pamplona Navarre, Spain, 31008Duplicate_Hospital Universitario A Coruna - CHUAC /ID# 203909 | A Coruña , Spain, 15006Hospital Universitario Vall de Hebron /ID# 202721 | Barcelona , Spain, 08035Hospital Clinic de Barcelona /ID# 202726 | Barcelona , Spain, 08036Hospital Universitario de Girona Doctor Josep Trueta /ID# 202644 | Girona , Spain, 17007Hospital Juan Ramon Jimenez /ID# 202727 | Huelva , Spain, 21005Hospital Universitario La Paz /ID# 202725 | Madrid , Spain, 28046Hospital Universitario de Salamanca /ID# 206359 | Salamanca , Spain, 37711Hospital Universitario Virgen Macarena /ID# 202722 | Seville , Spain, 41009Hospital Clinico Universitario de Valencia /ID# 209658 | Valencia , Spain, 46010Hospital Universitario y Politecnico La Fe /ID# 202720 | Valencia , Spain, 46026Hallands Hospital Halmstad /ID# 170815 | Halmstad Halland County, Sweden, 302 33Karolinska University Hospital Solna /ID# 224489 | Solna Stockholm County, Sweden, 171 64Alingsas lasarett /ID# 170814 | Alingsås Västra Götaland County, Sweden, 441 33Sodra Alvsborgs sjukhus /ID# 203078 | Borås Västra Götaland County, Sweden, 501 82Duplicate_Sahlgrenska University Hospital /ID# 169032 | Gothenburg Västra Götaland County, Sweden, 413 46Duplicate_Sahlgrenska University Hospital /ID# 169170 | Gothenburg Västra Götaland County, Sweden, 413 46Duplicate_Universitatsspital Zurich /ID# 171000 | Zurich Canton of Zurich, Switzerland, 8091Inselspital, Universitaetsspital Bern /ID# 170994 | Bern , Switzerland, 3010National Taiwan University Hospital /ID# 169805 | Taipei City Taipei, Taiwan, 100China Medical University Hospital /ID# 169803 | Taichung , Taiwan, 40447Taichung Veterans General Hospital /ID# 169802 | Taichung , Taiwan, 40705Linkou Chang Gung Memorial Hospital /ID# 169804 | Taoyuan City , Taiwan, 333Gazi Universitesi Tip Fakultes /ID# 217445 | Yenimahalle Ankara, Turkey (Türkiye), 06560Acibadem Kozyatagi Hospital /ID# 209404 | Kadıköy Istanbul, Turkey (Türkiye), 34742Sisli Etfal Train & Res Hosp /ID# 171327 | Şişli Istanbul, Turkey (Türkiye), 34371Duplicate_Erciyes University Medical Fac /ID# 171325 | Melikgazi Kayseri, Turkey (Türkiye), 38030Ankara Univ Medical Faculty /ID# 206408 | Ankara , Turkey (Türkiye), 06590Inonu Universitesi Turgut Ozal /ID# 201266 | Battalgazi/malatya , Turkey (Türkiye), 44280Mustafa Kemal University Medic /ID# 171328 | Hatay , Turkey (Türkiye), 31001Duplicate_Istanbul University Istanbul Medical Faculty /ID# 171365 | Istanbul , Turkey (Türkiye), 34093Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171326 | Istanbul , Turkey (Türkiye), 34899Mersin University Medical /ID# 171330 | Mersin , Turkey (Türkiye), 33343Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 167917 | Lviv Lviv Oblast, Ukraine, 79000MNE Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 222111 | Vinnytsia Vinnytsia Oblast, Ukraine, 21018Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 167918 | Kharkiv , Ukraine, 61037Kyiv City Clinical Hospital No.18 /ID# 207890 | Kyiv , Ukraine, 01030Medical Centre of "Ukrainian German Antiulcer Gastroenterology Centre BYK-KYIV" /ID# 203739 | Kyiv , Ukraine, 01030MNE KRC Kyiv Regional Clinical Hospital /ID# 202456 | Kyiv , Ukraine, 04106Duplicate_Royal United Hospitals Bath /ID# 169062 | Bath Bath And North East Somerset, United Kingdom, BA1 3NGWarrington and Halton Hospitals NHS Foundation Trust /ID# 171396 | Warrington Cheshire West And Chester, United Kingdom, WA5 1QGDisc_Barts Health NHS Trust - The Royal London Hospital /ID# 218830 | London Greater London, United Kingdom, E1 2ESKings College Hospital NHS Foundation Trust /ID# 169060 | London Greater London, United Kingdom, SE5 9RSSt George University Hospitals NHS Foundation Trust /ID# 205550 | London Greater London, United Kingdom, SW17 0QTTaunton and Somerset NHS Foundation Trust /ID# 209666 | Taunton Somerset, United Kingdom, TA1 5DAMersey and West Lancashire NHS teaching hospitals trust /ID# 209087 | Prescot Warrington, United Kingdom, L35 5DRUlster Hospital - South Eastern Health & Social Care Trust /ID# 205324 | Belfast , United Kingdom, BT16 1RHUniversity Hospitals Birmingham NHS Foundation Trust /ID# 169058 | Birmingham , United Kingdom, B15 2THThe Dudley Group NHS Foundation Trust /ID# 169057 | Dudley , United Kingdom, DY1 2HQLondon North West University Healthcare NHS Trust /ID# 169056 | Harrow , United Kingdom, HA1 3UJThe Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 169063 | Newcastle upon Tyne , United Kingdom, NE3 3HDDuplicate_Stockport NHS foundation trust /ID# 208717 | Stockport , United Kingdom, SK2 7JEThe Royal Wolverhampton NHS Trust /ID# 171395 | Wolverhampton , United Kingdom, WV10 0QP
Investigators
Study Director: ABBVIE INC., AbbVie