Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes

Primary Outcome Measures

1. Change in KCCQ (Kansas City Cardiomyopathy Questionnaire) clinical summary score
   Score on a scale of 0 to 100 where the score 100 means the least burden for the participant.
2. Change in body weight
   Percentage (%)

Secondary Outcome Measures

1. Change in 6-minute walking distance
   Measured in metres
2. Hierarchical composite of time to all-cause death
   Measured as total wins for each treatment group.
3. Hierarchical composite of number of heart failure events requiring hospitalisation or urgent heart failure visit
   Measured as total wins for each treatment group
4. Hierarchical composite of time to first heart failure event requiring hospitalisation or urgent heart failure visit
   Measured as total wins for each treatment group.
5. Hierarchical composite of difference at least 15 inKansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score change from baseline to 52 weeks
   Measured as total wins for each treatment group.
6. Hierarchical composite of difference at least 10 in KCCQ clinical summary score change from baseline to 52 weeks
   Measured as total wins for each treatment group.
7. Hierarchical composite of difference at least 5 in KCCQ clinical summary score change from baseline to 52 weeks
   Measured as total wins for each treatment group.
8. Hierarchical composite of difference at least 30 metres in six-minute walking distance change from baseline to 52 weeks (assessed by the win ratio)
   Measured as total wins for each treatment group.
9. Change in C-Reactive Protein
   Presented as ratio to baseline
10. Participant achieving 10% weight loss or more (Yes/No)
    Count of participants
11. Participant achieving 15% weight loss or more (Yes/No)
    Count of participants
12. Participant achieving 20% weight loss or more (Yes/No)
    Count of participants
13. Participant improving 5 points or more in KCCQ clinical summary score
    Count of participants
14. Participant improving 10 points or more in KCCQ clinical summary score (Yes/No)
    Count of participants
15. Change in KCCQ overall summary score
    Score on a scale of 0 to 100 where the score 100 means the least burden for the participant.
16. Participant achieving threshold for clinically meaningful within-subject change in KCCQ-CSS
    Count of participants
17. Participant achieving threshold for clinically meaningful within-subject change in 6MWD
    Count of participants
18. Change in waist circumference
    Measured in centimetre (cm)
19. Change in systolic blood pressure
    Measured in millimetre of mercury (mmHg)
20. Change in glycated haemoglobin (HbA1c)
    Measured in percentage (%)-point
21. Number of treatment emergent severe or clinically significant hypoglycaemia episodes
    Count of events