AGA Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease Guideline Summary - Guideline Central

Design and created by Guideline Central in participation with the American Gastroenterological Association.

Document Overview

Document Title: Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease

Authoring Society: American Gastroenterological Association

Document Publication Date: May 27, 2021

Page Last Reviewed/Updated: May 5, 2026

Document Type: Guideline

Country of Publication: United States

Full Text Freely Available: Yes

Full Text Guideline: www.gastrojournal.org/article/S0016-5085(21)00645-4/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F

Source Citation: Feuerstein JD, Ho EY, Shmidt E, Singh H, Falck-Ytter Y, Sultan S, Terdiman JP; American Gastroenterological Association Institute Clinical Guidelines Committee. AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn's Disease. Gastroenterology. 2021 Jun;160(7):2496-2508. doi: 10.1053/j.gastro.2021.04.022. PMID: 34051983.

Supplemental Implementation Resources

Document Scope, Criteria, and Use Cases

Document Objectives: Outpatient medical management of moderate to severe luminal and fistulizing crohn's disease (CD).

Scope: Management, Treatment

Diseases/Conditions (MeSH)

D015212 - Inflammatory Bowel Diseases

D003424 - Crohn Disease

D005402 - Fistula

D005747 - Gastric Fistula

D007412 - Intestinal Fistula

D015212 - Inflammatory Bowel Diseases

D003424 - Crohn Disease

D005402 - Fistula

D005747 - Gastric Fistula

D007412 - Intestinal Fistula

Keywords: Crohn's disease, IBD, fistulas, fistulizing, inflammatory bowel disease

Target Patient Population: Patients with moderate to severe luminal and fistulizing crohn's disease (CD)

Inclusion Criteria: Male, Female, Adult, Older Adult

Health Care Settings: Ambulatory, Outpatient

Intended Users: Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

Supplemental Methodology Resource: Technical Review

Number of Source Documents: 161

Includes peer/external review process?: Yes

Includes public comment process?: Yes

Methodologist involvement?: Yes

Patient involvement?: No

Includes multi-disciplinary group?: Yes

Includes systematic review?: Yes

Grades quality of strength of evidence?: Yes

Grades quality of strength of recommendation?: Yes

Discloses funding source?: Yes

Discloses conflicts of interest?: Yes

Includes benefits/harms analysis with recommendations?: No