Design and created by Guideline Central in participation with the European Association for the Study of the Liver.
European Association for the Study of the Liver
Publication Date: Nov 8, 2024
Page Last Updated: May 5, 2026
| Level | Criteria | Simple model for high, intermediate and low evidence |
| 1 | Systematic reviews (SR) (with homogeneity) of randomised-controlled trials (RCT) | Further research is unlikely to change our confidence in the estimate of benefit and risk |
| 2 | RCT or observational studies with dramatic effects; SR of lower quality studies (i.e. non-randomised, retrospective) | |
| 3 | Non-randomised-controlled cohort/follow-up study/control arm of randomised trial (systematic review is generally better than an individual study) | Further research (if performed) is likely to have an impact on our confidence in the estimate of benefit and risk and may change the estimate |
| 4 | Case-series, case-control, or historically controlled studies (systematic review is generally better than an individual study) | |
| 5 | Expert opinion (mechanism-based reasoning) | Any estimate of effect is uncertain |
| Grade | Wording | Criteria |
| Strong | Shall, should, is recommended. | Evidence, consistency of studies, risk-benefit ratio, patient preferences, ethical obligations, feasibility |
| Shall not, should not, is not recommended. | ||
| Weak or open | Can, may, is suggested. | |
| May not, is not suggested. |
European Association for the Study of the Liver. EASL-ERN Clinical Practice Guidelines on Wilson's disease. J Hepatol. 2025 Feb 22:S0168-8278(24)02706-5. doi: 10.1016/j.jhep.2024.11.007. Epub ahead of print. PMID: 40089450.
Provide recommendations, based on the best available evidence, for the diagnosis and management of Wilson’s disease (WD) for hepatologists, neurologists, general physicians, paediatricians, specialists in training and other healthcare professionals who provide care for this patient population.
D006527 - Hepatolenticular Degeneration
D006527 - Hepatolenticular Degeneration
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