Summary of Recommendations

Document Overview

Design and created by Guideline Central in participation with the European Academy of Allergy and Clinical Immunology.

Diagnosis of IgE-Mediated Food Allergy

European Academy of Allergy and Clinical Immunology

Publication Date: Oct 10, 2023

Page Last Updated: May 6, 2026

Grading of Recommendations, Assessment, Development, and Evaluation (GRADE)-Based Recommendations

Implications for:	Strong Recommendation (S)	Conditional Recommendation (C)
Patients	Most individuals in this situation would want the recommended course of action, and only a small proportion would not.	The majority of individuals in this situation would want the suggested course of action, but many would not.
Clinicians	Most individuals should receive the intervention. Adherence to this recommendation according to the guideline could be used as a quality criterion or performance indicator. Formal decision aids are not likely to be needed to help individuals make decisions consistent with their values and preferences.	Recognize that different choices will be appropriate for individual patients and that you must help each patient arrive at a management decision consistent with his or her values and preferences. Decision aids may be useful in helping individuals to make decisions consistent with their values and preferences.
Policy	The recommendation can be adopted as policy in most situations.	Policymaking will require substantial debate and involvement of various stakeholders.

Certainty in the Evidence
High	H	Low	L
Moderate	M	Very Low	VL

Source: Grading of Recommendations Assessment, Development and Evaluation Working Group (Schunemann HJ et al. Am J Respir Crit Care Med. 2006;174:605-14. Guyatt GH et al. BMJ 2008;336:924-6).

Document Overview

Document Title: Diagnosis of IgE-Mediated Food Allergy

Authoring Society: European Academy of Allergy and Clinical Immunology

Document Publication Date: Oct 10, 2023

Page Last Reviewed/Updated: May 6, 2026

Document Type: Guideline

Country of Publication: European

Full Text Freely Available: Yes

Full Text Guideline: onlinelibrary.wiley.com/doi/10.1111/all.15902

Source Citation: Santos AF, Riggioni C, Agache I, Akdis CA, Akdis M, Alvarez-Perea A, Alvaro-Lozano M, Ballmer-Weber B, Barni S, Beyer K, Bindslev-Jensen C, Brough HA, Buyuktiryaki B, Chu D, Del Giacco S, Dunn-Galvin A, Eberlein B, Ebisawa M, Eigenmann P, Eiwegger T, Feeney M, Fernandez-Rivas M, Fisher HR, Fleischer DM, Giovannini M, Gray C, Hoffmann-Sommergruber K, Halken S, Hourihane JO, Jones CJ, Jutel M, Knol E, Konstantinou GN, Lack G, Lau S, Marques Mejias A, Marchisotto MJ, Meyer R, Mortz CG, Moya B, Muraro A, Nilsson C, Lopes de Oliveira LC, O'Mahony L, Papadopoulos NG, Perrett K, Peters RL, Podesta M, Poulsen LK, Roberts G, Sampson HA, Schwarze J, Smith P, Tham EH, Untersmayr E, Van Ree R, Venter C, Vickery BP, Vlieg-Boerstra B, Werfel T, Worm M, Du Toit G, Skypala I. EAACI guidelines on the diagnosis of IgE-mediated food allergy. Allergy. 2023 Dec;78(12):3057-3076. doi: 10.1111/all.15902. Epub 2023 Oct 10. PMID: 37815205.

Document Scope, Criteria, and Use Cases

Document Objectives: This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE-mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.

Scope: Assessment and Screening, Diagnosis

Diseases/Conditions (MeSH)

D000486 - Allergy and Immunology

D005512 - Food Hypersensitivity

D007073 - Immunoglobulin E

D000486 - Allergy and Immunology

D005512 - Food Hypersensitivity

D007073 - Immunoglobulin E

Keywords: IgE-mediated food allergy, food allergies, specific IgE

Target Patient Population: Patients with diagnosed or suspected IgE-mediated food allergy

Target Provider Population: Allergist, immunologist, primary care physician, dietitian, pediatrician, gastroenterologist

Inclusion Criteria: Male, Female, Adolescent, Adult, Child, Older Adult

Health Care Settings: Ambulatory, Laboratory Services

Intended Users: Nurse, Nurse Practitioner, Physician, Physician Assistant