Design and created by Guideline Central in participation with the Barcelona Clinic Liver Cancer.
Reig M, Sanduzzi-Zamparelli M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, Díaz A, Llarch N, Iserte G, Mollà M, Kelley RK, Galle PR, Mazzaferro V, Salem R, Sangro B, Singal A, Vogel A, Yanagihara TK, Ayuso C, Torres F, Bruix J. BCLC strategy for prognosis prediction and treatment recommendations: The 2025 update. J Hepatol. 2025 Oct 27:S0168-8278(25)02571-1. doi: 10.1016/j.jhep.2025.10.020. Epub ahead of print. PMID: 41151697.
The 2025 BCLC update incorporates recent advances in the field of treatment recommendations for hepatocellular carcinoma while preserving its simplicity. Each stage remains directly linked to its evidence-based first-option treatment. The BCLC algorithm provides guidance to evaluate patient prognosis and propose a therapeutic strategy according to the current scientific evidence. These updates are particularly important for clinicians, tumor boards, and guideline developers, as well as for patients and caregivers who face complex choices in real-world practice. In practical terms, the prognostic capacity of BCLC is embedded within person-centered decision-making, fostering iterative treatment planning and laying the foundation for future studies assessing the clinical impact of CUSE, while acknowledging the need for validation and variability in implementation across healthcare settings.
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