Design and created by Guideline Central in participation with the American Society of Clinical Oncology.
American Society of Clinical Oncology
Publication Date: Mar 10, 2026
Page Last Updated: May 5, 2026
| Quality of Evidence | ||
|---|---|---|
| Term | Definitions | |
| H | - High | We are very confident that the true effect lies close to that of the estimate of the effect |
| M | - Moderate | We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. |
| L | - Low | Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. |
| VL | - Very Low | We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect. |
| Strength of Recommendation | ||
|---|---|---|
| Term | Definitions | |
| S | - Strong | In recommendations for an intervention, the desirable effects of an intervention outweigh its undesirable effects. In recommendations against an intervention, the undesirable effects of an intervention outweigh its desirable effects. All or almost all informed people would make the recommended choice for or against an intervention. |
| W | - Weak | In recommendations for an intervention, the desirable effects probably outweigh the undesirable effects, but appreciable uncertainty exists. In recommendations against an intervention, the undesirable effects probably outweigh the desirable effects, but appreciable uncertainty exists. Most informed people would choose the recommended course of action, but a substantial number would not. |
GRADE Handbook, Schünemann, et al. 2013.
Gilligan T, Bohlke K, Alpert AB, et al. Patient-Clinician Communication: ASCO Guideline Update. J Clin Oncol. 2026 March 10. doi: 10.1200/JCO-26-00118
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