Recommendations

Document Overview

Design and created by Guideline Central in participation with the American College of Gastroenterology, American Gastroenterological Association, and American Society for Gastrointestinal Endoscopy.

Genetic Evaluation and Management of Lynch Syndrome

American College of Gastroenterology

American Gastroenterological Association

American Society for Gastrointestinal Endoscopy

Publication Date: Aug 1, 2014

Page Last Updated: May 5, 2026

American College of Gastroenterology Evidence Grading System

Level of evidence	Description
I	Evidence obtained from at least 1 well-designed and well-controlled randomized controlled trial that has either: Cancer end point with mortality or incidence, or Intermediate end point
II	Evidence obtained from well-designed and well-con- ducted nonrandomized controlled trials that have: Cancer end point Intermediate end point
III	Evidence obtained from well-designed and well-con- ducted cohort or case-control studies with: Cancer end point Intermediate end point
IV	Evidence from descriptive studies with: Cancer end point Intermediate end point
V	Conclusions from authorities based on clinical experi ence, descriptive studies and/or expert committees

Document Overview

Document Title: Genetic Evaluation and Management of Lynch Syndrome

Authoring Societies

American College of Gastroenterology

American Gastroenterological Association

American Society for Gastrointestinal Endoscopy

Document Publication Date: Aug 1, 2014

Page Last Reviewed/Updated: May 5, 2026

Document Type: Guideline

Country of Publication: United States

Full Text Freely Available: Yes

Full Text Guideline: www.gastrojournal.org/article/S0016-5085(14)00448-X/fulltext

Document Scope, Criteria, and Use Cases

Scope: Assessment and Screening, Diagnosis, Management

Diseases/Conditions (MeSH)

D055847 - Lynch Syndrome II

Keywords: Lynch syndrome, colorectal cancer, genetic testing

Inclusion Criteria: Male, Female, Adult, Older Adult

Health Care Settings: Ambulatory

Intended Users: Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

Supplemental Methodology Resource: Methodology Supplement

Number of Source Documents: 164

Includes peer/external review process?: Yes

Includes public comment process?: No

Methodologist involvement?: Yes

Patient involvement?: No

Includes multi-disciplinary group?: Yes

Includes systematic review?: Yes

Grades quality of strength of evidence?: Yes

Grades quality of strength of recommendation?: Yes

Discloses funding source?: Yes

Discloses conflicts of interest?: Yes

Includes benefits/harms analysis with recommendations?: Yes

Grade	Rating of evidence	Impact of potential future research
A	High quality	Very unlikely to change confidence in the estimate of effect
B	Moderate quality	Likely to have an important impact on confidence and might change estimate of effect
C	Low quality	Very likely to have an important impact on confidence in the estimate of effect and is likely to change the estimate
D	Very low quality	Any estimate of effect is very uncertain

Genetic Evaluation and Management of Lynch Syndrome

Recommendations

GENETIC TESTING

LYNCH SYNDROME MANAGEMENT

American College of Gastroenterology Evidence Grading System

Document Overview

Document Scope, Criteria, and Use Cases

Recommendation Development Processes & Methodology