ASH Sickle Cell Disease: Transfusion Support Guideline Summary - Guideline Central

Document Overview

Design and created by Guideline Central in participation with the American Society of Hematology.

Document Overview

Document Title: Sickle Cell Disease: Transfusion Support

Authoring Society: American Society of Hematology

Document Publication Date: Jan 27, 2020

Page Last Reviewed/Updated: May 5, 2026

Document Type: Guideline

Country of Publication: United States

Full Text Freely Available: Yes

Full Text Guideline: ashpublications.org/bloodadvances/article/4/2/327/440607/American-Society-of-Hematology-2020-guidelines-for

Source Citation: Chou ST, Alsawas M, Fasano RM, Field JJ, Hendrickson JE, Howard J, Kameka M, Kwiatkowski JL, Pirenne F, Shi PA, Stowell SR, Thein SL, Westhoff CM, Wong TE, Akl EA. American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support. Blood Adv. 2020 Jan 28;4(2):327-355. doi: 10.1182/bloodadvances.2019001143. PMID: 31985807; PMCID: PMC6988392.

Supplemental Implementation Resources

Document Scope, Criteria, and Use Cases

Document Objectives: Our objective was to develop evidence-based guidelines to support patients, clinicians, and other healthcare professionals in their decisions about transfusion support for SCD and the management of transfusion-related complications.

Scope: Management, Prevention

Diseases/Conditions (MeSH)

D000755 - Anemia, Sickle Cell

D001803 - Blood Transfusion

D000755 - Anemia, Sickle Cell

D001803 - Blood Transfusion

Keywords: sickle cell disease, transfusion

Target Patient Population: Adults and children with sickle cell disease

Inclusion Criteria: Male, Female, Adolescent, Adult, Child

Health Care Settings: Hospital, Outpatient

Intended Users: Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

Number of Source Documents: 169

Includes peer/external review process?: Yes

Includes public comment process?: No

Methodologist involvement?: Yes

Patient involvement?: No

Includes multi-disciplinary group?: Yes

Includes systematic review?: Yes

Grades quality of strength of evidence?: Yes

Grades quality of strength of recommendation?: Yes

Discloses funding source?: Yes

Discloses conflicts of interest?: Yes

Includes benefits/harms analysis with recommendations?: Yes