Guideline statements

Document Overview

Design and created by Guideline Central in participation with the American Society for Radiation Oncology.

Role Of Postoperative Radiation Therapy For Endometrial Cancer

American Society for Radiation Oncology

Publication Date: Jun 1, 2017

Page Last Updated: May 5, 2026

American Society for Radiation Oncology Grading System

Grade	Strength of Recommendation
Strong	For the Patient	For the Clinician
Strong	Most individuals in this situation would want the recommended course of action and only a small proportion would not.	Most individuals in this situation would want the recommended course of action and only a small proportion would not. The majority of individuals in this situation would want the suggested course of action, but many would not.
Conditional (weak)	The majority of individuals in this situation would want the suggested course of action, but many would not.	Different choices will be appropriate for different patients. Decision aids may well be useful in helping individuals making decisions consistent with their values and preferences. Clinicians should expect to spend more time with patients when working toward a decision.

Grade	Quality of Evidence
High	We are very confident that the true effect lies close to that of the estimate of the effect.
Moderate	We are moderately confident in the effect estimate. The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low	Our confidence in the effect estimate is limited. The true effect may be substantially different from the estimate of the effect.
Expert Opinion	A lower quality of evidence, including expert opinion, does not imply that the recommendation is conditional. Many important clinical questions addressed in guidelines do not lend themselves to clinical trials but there still may be consensus that the benefits of a treatment or diagnostic test clearly outweigh its risks and burden.

Document Overview

Document Title: Role Of Postoperative Radiation Therapy For Endometrial Cancer

Authoring Society: American Society for Radiation Oncology

Document Publication Date: Jun 1, 2017

Page Last Reviewed/Updated: May 5, 2026

Document Type: Guideline

Country of Publication: United States

Full Text Freely Available: Yes

Full Text Guideline: www.practicalradonc.org/article/S1879-8500(14)00005-8/fulltext

Source Citation: https://doi.org/10.1016/j.prro.2014.01.003

Supplemental Implementation Resources

Document Scope, Criteria, and Use Cases

Document Objectives: To present evidence-based guidelines for adjuvant radiation in the treatment of endometrial cancer.

Scope: Management, Treatment

Diseases/Conditions (MeSH)

D018787 - Radiation Oncology

D011827 - Radiation

D016889 - Endometrial Neoplasms

D018787 - Radiation Oncology

D011827 - Radiation

D016889 - Endometrial Neoplasms

Keywords: Adjuvant Radiation Therapy, endometrial cancer, radiation therapy

Target Patient Population: Patients with endometrial cancer

Inclusion Criteria: Female, Adolescent, Adult, Older Adult

Health Care Settings: Ambulatory, Hospital, Outpatient, Radiology Services

Intended Users: Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

Supplemental Methodology Resources: Evidence Tables Data Supplement Data Supplement Data Supplement

Number of Source Documents: 29

Includes peer/external review process?: Yes

Includes public comment process?: No

Methodologist involvement?: Yes

Patient involvement?: No

Includes multi-disciplinary group?: Yes

Includes systematic review?: Yes

Grades quality of strength of evidence?: Yes

Grades quality of strength of recommendation?: Yes

Discloses funding source?: Yes

Discloses conflicts of interest?: Yes

Includes benefits/harms analysis with recommendations?: Yes

Role Of Postoperative Radiation Therapy For Endometrial Cancer

Guideline statements

Which patients with endometrioid endometrial cancer require no additional therapy after hysterectomy?

Which patients with endometrioid endometrial cancer should receive vaginal cuff radiation?

Which women with early stage endometrial cancer should receive postoperative external beam radiation?

Which women with stage III-IVA endometrial cancer should receive postoperative external beam radiation?

When should brachytherapy be used in addition to external beam radiation?

How should radiation therapy and chemotherapy be integrated in the management of endometrial cancer?

American Society for Radiation Oncology Grading System

Document Overview

Supplemental Implementation Resources

Document Scope, Criteria, and Use Cases

Recommendation Development Processes & Methodology