Recommendations

Document Overview

Design and created by Guideline Central in participation with the American College of Chest Physicians.

Antithrombotic And Thrombolytic Therapy For Ischemic Stroke

American College of Chest Physicians

Publication Date: Feb 1, 2012

Page Last Updated: May 5, 2026

Grading Recommendations

Grade	Description
1	Recommendation: indicates confidence that the benefits of the intervention clearly outweigh harms.
2	Suggestion: indicates greater uncertainty: although the benefits of the statement are still viewed as outweighing the harms, balance of benefits and harms is more difficult to judge, or the benefits or the harms may be less clear. With a suggestion, patient values and preferences may be more variable, and this can influence the clinical decision that is ultimately made.
Grade	Strength of Evidence
A	High: high confidence that the evidence reflects the true effect. Further research is very unlikely to change our confidence in the estimate of effect.
B	Moderate: moderate confidence that the evidence reflects the true effect. Further research may change our confidence in the estimate of effect and may change the estimate.
C	Low: low confidence that the evidence reflects the true effect. Further research is likely to change our confidence in the estimate of effect and is likely to change the estimate.

Document Overview

Document Title: Antithrombotic And Thrombolytic Therapy For Ischemic Stroke

Authoring Society: American College of Chest Physicians

Document Publication Date: Feb 1, 2012

Page Last Reviewed/Updated: May 5, 2026

Document Type: Guideline

Country of Publication: United States

Full Text Freely Available: Yes

Full Text Guideline: journal.chestnet.org/article/S0012-3692(12)60133-0/fulltext

Source Citation: DOI: https://doi.org/10.1378/chest.11-2302

Document Scope, Criteria, and Use Cases

Document Objectives: This article provides recommendations on the use of antithrombotic therapy in patients with stroke or transient ischemic attack (TIA).

Scope: Management, Prevention, Treatment

Diseases/Conditions (MeSH)

D000925 - Anticoagulants

D000991 - Antithrombins

D020521 - Stroke

D002546 - Ischemic Attack, Transient

D000925 - Anticoagulants

D000991 - Antithrombins

D020521 - Stroke

D002546 - Ischemic Attack, Transient

Keywords: Acute Ischemic Stroke, Antithrombotic Agents, Stroke Prevention, Transient Ischemic Attack, stroke

Target Patient Population: patients with stroke or transient ischemic attack (TIA).

Inclusion Criteria: Male, Female, Adolescent, Adult, Older Adult

Health Care Settings: Ambulatory, Emergency Care, Hospital, Operating and Recovery Room, Outpatient

Intended Users: Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

Supplemental Methodology Resource: Data Supplement

Number of Source Documents: 144

Includes peer/external review process?: Yes

Includes public comment process?: No

Methodologist involvement?: Yes

Patient involvement?: Yes

Includes multi-disciplinary group?: Yes

Includes systematic review?: Yes

Grades quality of strength of evidence?: Yes

Grades quality of strength of recommendation?: Yes

Discloses funding source?: Yes

Discloses conflicts of interest?: Yes

Includes benefits/harms analysis with recommendations?: Yes

Antithrombotic And Thrombolytic Therapy For Ischemic Stroke

Recommendations

Acute Ischemic Stroke Treatment

VTE Prevention in Ischemic and Hemorrhagic Stroke

Secondary Stroke Prevention

Cerebral Venous Sinus Thrombosis

Grading Recommendations

Document Overview

Document Scope, Criteria, and Use Cases

Recommendation Development Processes & Methodology