Guideline Video

Guideline Resources

  • Anticoagulant Prophylaxis of Pediatric Patients at Risk of Venous Thromboembolism
  • American Society of Hematology and International Society on Thrombosis and Haemostasis
  • April 8, 2026
  • Summary
  • Full-text

Video Transcription

Just published April 8th, 2026, the American Society of Hematology and International Society on Thrombosis and Haemostasis’ newest guideline on Anticoagulant Prophylaxis of Pediatric Patients at Risk of Venous Thromboembolism.

The purpose of this guideline is to provide evidence-based recommendations to support clinical decision-making for anticoagulant prophylaxis for preventing pediatric venous thromboembolism.

In today’s rapid update, we’ll just be going over a summary of recommendations so for the full guideline, make sure to check it out on guidelinecentral.com

Let’s get started. 

  • For pediatric patients with leukemia or lymphoblastic lymphoma, the guideline suggests either  anticoagulant prophylaxis or no anticoagulant prophylaxis. The guideline also suggests no antithrombin supplementation. For pediatric patients with solid tumors, the guideline suggests no anticoagulant prophylaxis. 
  • For pediatric patients receiving total parental nutrition (TPN) more than 60 days, the guideline suggests anticoagulant prophylaxis. 
  • For pediatric patients with a short term central venous access device (CVAD), the guideline suggests no anticoagulant prophylaxis. For pediatric patients with medium/long term CVAD in the absence of TPN or cancer, the guideline suggests no anticoagulant prophylaxis. 
  • For pediatric patients with antiphospholipid antibody syndrome, the guideline suggests secondary anticoagulant prophylaxis. For patients with persistently positive antiphospholipid antibodies, the guideline suggests no primary anticoagulant prophylaxis.
  • For pediatric patients with trauma, the guideline suggests no anticoagulant prophylaxis.
  • For hospitalized pediatric patients, the guideline suggests no anticoagulant prophylaxis. 
  • For critically ill pediatric patients with or without a CVAD, the guideline suggests no anticoagulant prophylaxis. 
  • For children undergoing noncardiac surgery, the guideline suggests no anticoagulant prophylaxis. 

And there you have it. Make sure to check out the full guideline from the American Society of Hematology and International Society on Thrombosis and Haemostasis and other related clinical decision support tools at guidelinecentral.com.

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