Health awareness months foster patient education on health issues they or their loved ones may have or are at risk of developing. Clinicians can help answer patient questions and ease concerns with education on medical topics through awareness events. Additionally, awareness leads to better outcomes through earlier diagnosis, which is particularly helpful in diagnosing neurological issues.

Neurosurgery Awareness Month helps educate the public on the vital role that neurosurgeons have in their communities. This August, take a few moments to consider some of the latest insights and research into neurosurgery-related topics.

Today, we’re showcasing some of the most recent articles on brain tumors posted recently across medical journals. The topics include a study on pediatric brain tumors, how radiation therapy for brain tumors may lead to stroke, and more.

A Review of Epilepsy Syndromes and Epileptogenic Mechanism Affiliated with Brain Tumor Related Genes

  • Gene, August 2025
  • Description: Besides reviewing the well-studied genes like TSC1 and TSC2, we identified several under-discovered brain-tumor-related genes, including TP53, CIC, IDH1 and NOTCH1, that warrant future exploration due to the existence of clinical or in vivo evidence substantiating their pathogenic role in epileptogenesis. We also propounded some methodologies that can be applied in future research to enhance the study of the epileptogenic mechanism of brain-tumor-related genes. To date, this article covers the greatest number of brain-tumor-related genes.
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Prevalence and Risk Factors for Asymptomatic Venous Thromboembolism in Patients with Primary Brain Tumors

  • iScience, August 2025
  • Description: Patients with primary brain tumors have a high risk of venous thromboembolism (VTE). This study aims to estimate the prevalence of asymptomatic VTE and to identify risk factors and biomarkers for asymptomatic VTE in patients with brain tumors by screening for asymptomatic LE-DVT.
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Cerebral Open Flow Microperfusion (cOFM)-HILIC-HRMS Platform for in Vivo and in Situ Monitoring of Tumor Microenvironment in Glioblastoma

  • Analytica Chimica Acta, August 2025
  • Description: Glioblastoma exhibits a very poor prognosis and profound metabolic alterations associated with its aggressiveness. Examining tumor metabolic states is crucial for identifying potential therapeutic targets, enabling personalized medicine applications. However, direct access to the functional glioblastoma tumor microenvironment in vivo is highly challenging, particularly due to the tumor location and risk of blood-brain-barrier disruption. Here, [researchers] developed a novel research platform combining the innovative sampling technology cerebral open flow microperfusion and HILIC-HRMS-based metabolomics to comprehensively characterize the local metabolic phenotype of human glioblastoma in xenograft animal model.
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Frequency, Risk Factors, and Outcomes of Strokes in Patients with Primary Glioma After Cranial Radiation Therapy

  • Neurology, August 2025
  • Description: Radiation therapy is the mainstay of therapy for patients with glioma. While this treatment modality can improve survival, treatment-related complications may include radiation-induced vasculopathy and increased risk of stroke. We aimed to evaluate the stroke frequency, associated risk factors, and outcomes after cranial radiation therapy in patients with glioma.
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The COMBAT Project: Study Protocol for the Development of a Core Outcome Set for Morbidity Following Surgery in Paediatric Brain Tumour Patients

  • Trials, August 2025
  • Description: Postoperative morbidity reporting following surgery for paediatric brain tumours is poor. This is due to variability of outcomes measured and reported and the lack of a common language when reporting adverse outcomes. One solution is to develop a core outcome set which will stipulate the minimum postoperative outcomes that should be reported. The COMBAT (Core Postoperative Morbidity Set for Paediatric Brain Tumours) Project will develop a core set of adverse outcomes that can be applied to paediatric brain tumour patients undergoing surgery.
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Enhanced MRI Brain Tumor Detection Using Deep Learning in Conjunction with Explainable AI SHAP Based Diverse and Multi Feature Analysis

  • Scientific Reports, August 2025
  • Description: This study investigates the synergy among multiple feature representation schemes such as local Binary Patterns (LBP), Gabor filters, Discrete Wavelet Transform, Fast Fourier Transform, Convolutional Neural Networks (CNN), and Gray-Level Run Length Matrix alongside five learning algorithms namely: k-nearest Neighbor, Random Forest, Support Vector Classifier (SVC), and probabilistic neural network (PNN), and CNN.
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Multimodal Nanoparticle Co-Delivering Bevacizumab and Dichloroacetate for Dual Targeting of Neoangiogenesis and Hyperglycolysis in Glioblastoma Treatment

  • Journal of Controlled Release: Official Journal of the Controlled Release Society, August 2025
  • Description: Encapsulation of bevacizumab into polymeric nanoparticles has shown promise in improving drug brain bioavailability after intranasal administration. Nevertheless, therapeutic efficacy remains limited by tumor cells adopting a hyperglycolytic metabolism. Here, [researchers] optimized BDNP, a multidrug formulation for GBM treatment, by co-entrapment of the anti-angiogenic bevacizumab and the glycolysis inhibitor dichloroacetate into poly(lactic-co-glycolic) acid nanoparticles.
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Look forward to more journal-focused topics in the coming weeks. 

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