The 2025 Association for Diagnostics & Laboratory Medicine (ADLM) annual conference just wrapped up and we have an overview of some of the exciting research presented at the event that is related to endocrinology and metabolism.
A few weeks ago, we previewed some of the many educational sessions that were planned for ADLM 2025. Topics included emergency department toxicology reporting, best practices for pediatric and rural patients, and more.
For a complete overview of research posters presented at the ADLM 2025 conference, you can check out the full rundown on the event’s website. The official ADLM 2025 website offers multiple ways to view posters; an in-app option and in-browser option are available for your convenience.
- Objective: This study aims to assess the incidence of hyponatremia and syndrome of inappropriate antidiuretic hormone (SIADH) secretion in patients with hematolymphoid malignancies at our institution.
- Conclusion: Patients with hematolymphoid malignancies are at increased risk for developing hyponatremia, with a notable prevalence of SIADH. Both the malignancy and its associated treatments contribute to disruptions in sodium balance.
- Objective: Glycated hemoglobin (A1c) and the oral glucose tolerance test (OGTT) are used routinely to diagnose or to evaluate increased risk for diabetes mellitus (DM). However, A1c and OGTT were not defined on the basis of the principal pathophysiological abnormalities of type 2 DM, i.e. impaired tissue sensitivity to insulin and failure of pancreatic b-cells to compensate IR. To gain a deeper insight into the matter, we correlate both, OGTT and A1c to HOMA-IR index, in non-diabetic subjects.
- Conclusion: Since patients had A1c and OGTT performed on the same day and time, reflecting the same metabolic state, our data show that, although both parameters showed a positive correlation with HOMA-IR, this was more relevant with OGTT.
- Objective: The ADVIA Centaur Anti-Thyroid Peroxidase II (aTPOII) and ADVIA Centaur Anti-Thyroglobulin II (aTgII) evaluate the clinical performance of these assays on the ADVIA Centaur system, providing insights into their diagnostic potential and utility in clinical practice.
- Conclusion: The ADVIA Centaur aTPOII and aTgII assays demonstrated acceptable sensitivity, specificity, and great concordance when compared with the predicate device. Both assays fulfill requirements for use to aid in the diagnosis of autoimmune thyroid disease.
- Objective: This study investigated whether A1C results are associated with red blood cell (RBC) parameters in patients with type 2 diabetes.
- Conclusion: Elevated RBC parameters may skew A1C measurements, making it essential to consider these factors when interpreting results, especially in individuals with conditions such as polycythemia, androgen replacement, dehydration, or other disorders affecting RBC parameters.
- Objective: The goal of this study was to provide high-affinity monoclonal antibodies that are suitable for the development of TSH assays with a functional sensitivity of 0.001 µIU/ml, which recognize the TSH variant R55G.
- Conclusion: Antibodies recognized the TSH variant R55G, thus enabling the accurate detection of TSH in serum samples from individuals carrying this mutation. Neither individual antibodies nor immunoassays using these antibodies had cross-reactivity with other human glycoprotein hormones.
- Objective: The study aims to compare the differences in primary aldosteronism (PA) screening based on traditional aldosterone cut-offs using LC-MS/MS and radioimmunoassay, respectively.
- Conclusion: Significant discrepancies in plasma aldosterone measurements between assays have been observed, and the conventional cut-offs derived from immunoassays are not applicable in patients with aldosterone measured by LC-MS/MS.
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