Advancements in cancer treatments are rapidly evolving, making oncology the medical specialty that experiences the highest number of new and updated guidelines each year. This Guidelines Rundown article will examine the new ASCO, NCCN and other oncology guidelines published in January 2025.

National Comprehensive Cancer Network, or NCCN for short, is one of two organizations that publishes the most clinical practice guidelines in the medical oncology specialty area, the other being the American Society of Clinical Oncology (ASCO). Both NCCN and ASCO Clinical Practice Guidelines in Oncology provide various levels of recommendations for preventive, diagnostic, treatment, and supportive services that are intended to help deliver better quality care, and improve patient outcomes. While ASCO prioritizes a rigorous guideline development methodology, the NCCN prioritizes speed. Both offer tremendous value with their guidelines to oncologists across the US, and the globe.

With that said, let’s take a look at the new or newly updated clinical practice guidelines published by both NCCN and ASCO (and a couple others) during the month of January 2025. 

ASCO Guidelines Published in January 2025
  1. Neoadjuvant Chemotherapy for Newly Diagnosed, Advanced Ovarian Cancer
  2. Treatment of Pleural Mesothelioma
  3. Germline and Somatic Genomic Testing for Metastatic Prostate Cancer

Links to each summary are embedded above. From there you can also click through to view the full text, or click to access the pocket guides. Mesothelioma also offers a free patient summary!

NCCN Guidelines Published in January 2025
  1. Penile Cancer
  2. Neuroendocrine and Adrenal Tumors
  3. Non-Small Cell Lung Cancer
  4. Histiocytic Neoplasms
  5. Kidney Cancer
  6. Biliary Tract Cancers
  7. Hepatocellular Carcinoma
  8. Ampullary Adenocarcinoma
  9. Small Cell Lung Cancer
  10. Cancer-Related Fatigue
  11. Kaposi Sarcoma
  12. Non-Small Cell Lung Cancer
  13. Mesothelioma: Peritoneal
  14. Mesothelioma: Pleural
  15. Thyroid Carcinoma
  16. Basal Cell Skin Cancer
  17. Anal Carcinoma
  18. Rectal Cancer
  19. Colon Cancer
  20. Testicular Cancer
  21. Squamous Cell Skin Cancer
  22. Small Bowel Adenocarcinoma
  23. Pediatric Central Nervous System Cancers
  24. Head and Neck Cancers
  25. Merkel Cell Carcinoma
  26. Myelodysplastic Syndromes
  27. Neuroendocrine and Adrenal Tumors
  28. Bladder Cancer
  29. Acute Myeloid Leukemia
  30. Melanoma: Cutaneous
  31. Castleman Disease
  32. Breast Cancer Risk Reduction
  33. Hodgkin Lymphoma
  34. Uterine Neoplasms
  35. Vaginal Cancer
  36. Breast Cancer
  37. Cervical Cancer
  38. Gestational Trophoblastic Neoplasia

A free account registration on the NCCN website is required in order to access the above NCCN guidelines. Once logged in you can view any of the above listed guidelines from NCCN here. 

Other Guidelines in Oncology Published In January 2025:
  1. Surgical Management of Oligometastatic Non-Small Cell Lung Cancer (STS)
  2. Fibroblast Activation Protein (FAP) PET (SNMMI / EANM)


So there you have it - January 2025 was clearly a very busy month in the world on Oncology Clinical Guidelines!

Thank you for reviewing the oncology guidelines from January 2025. If there are any guidelines that we may have overlooked, please feel free to inform us. Additionally, we welcome suggestions for future topics to cover in our Guidelines Rundown Series. We look forward to hearing from you and don't forget to sign up for alerts and stay informed on the latest published guidelines and articles.

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