Multiple myeloma is challenging to diagnose because its presentation is often nonspecific and overlaps with other conditions. Fatigue and skeletal pain can often be attributed to other conditions or simply just general aging. Definitive diagnosis requires specialized assessments. The following multiple myeloma guidelines represent some of the more recent options that better equip physicians with evidence-based recommendations from clinical societies.

The following guidelines focused on multiple myeloma come from the International Myeloma Working Group or the European Hematology Association and range in publication from 2022 through 2025. 

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