Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity. Journal Abstract - Guideline Central

Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity.

Published: 2025 Nov 28

Authors

, , , , , , , , , , , , , ,

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Significant morbidity and early mortality necessitate early intervention. This study harnessed SLE-associated immune dysregulation to create a Lupus Classification Risk Index (LCRII) and Lupus Disease Activity Immune Index (LDAII) that identified individuals at risk for SLE classification and disease activity.

Keywords: Autoantibodies, Autoimmunity, Cytokines, Inflammation, Systemic Lupus Erythematosus

Source

Lupus science & medicine

Publication Type

Journal Article

Language

English

PubMed ID

41314814

MeSH terms

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