Comprehensive Cytopathologic, Flow Cytometric and Immunocytochemical Analysis of a Challenging Case of Small Cell Variant of Anaplastic Large T-Cell Lymphoma in a Child. Journal Abstract - Guideline Central

Comprehensive Cytopathologic, Flow Cytometric and Immunocytochemical Analysis of a Challenging Case of Small Cell Variant of Anaplastic Large T-Cell Lymphoma in a Child.

Published: 2026 Mar

Authors

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Abstract

Anaplastic large cell lymphoma (ALCL) is a high-grade non-Hodgkin lymphoma, accounting for approximately 3% of all non-Hodgkin lymphomas in adults and 15% of NHL in children. Around 70% of ALCLs show conventional morphology; however, several subtypes exist, such as the lympho-histiocytic, small cell, sarcomatous, giant cell-rich and signet-ring subtypes. The small cell variant of ALCL often presents as a diagnostic challenge due to its distinctive morphology, which differs significantly from the conventional ALCL.

Keywords: ALK, CD30, anaplastic large cell lymphoma, cytology, flow cytometry, immunocytochemistry, paediatric lymphoma, small cell anaplastic large cell lymphoma

Source

Cytopathology : official journal of the British Society for Clinical Cytology

Publication Type

Case Reports

Language

English

PubMed ID

41361506

MeSH terms

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