Transient congenital hypothyroidism (CH) caused by maternal thyrotropin receptor-blocking antibody (TBAb) has been uncommonly reported. Goiter is a significant indicator of fetal thyroid dysfunction that may facilitate early identification, but some cases present without this manifestation. This report describes a case of CH attributed to maternal elevated levels of thyroid-stimulating hormone receptor antibody (TRAb) with normal thyroid size, and further provides a systematic review of neonatal thyroid size classification in other CH cases from the literature.
Keywords: Congenital hypothyroidism, Thyroid-stimulating hormone receptor antibody, Thyrotropin receptor-blocking antibody
BMC pregnancy and childbirth
Journal Article
English
41462154
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