Case Report: A case of post-viral inflammatory insomnia: observed sleep restoration associated with histamine-targeted interventions and implications for mast cell pathways. Journal Abstract - Guideline Central

Case Report: A case of post-viral inflammatory insomnia: observed sleep restoration associated with histamine-targeted interventions and implications for mast cell pathways.

Published: 2025

Authors

,

Abstract

Mast cell-mediated inflammation has been proposed as a potential contributor to neuroinflammatory insomnia and dysautonomia, but objective clinical documentation remains limited. Histamine and related immune mediators can disrupt circadian rhythm, arousal systems, and autonomic stability. Conventional pharmacological therapies for sleep restoration often fail to address these inflammatory mechanisms.

Keywords: dysautonomia, histamine, inflammation, inflammatory insomnia, mast cells, post-viral syndrome, sleep regulation

Source

Frontiers in sleep

Publication Type

Case Reports

Language

English

PubMed ID

41640426

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