The locus coeruleus is among the earliest brain regions affected by tau pathology in Alzheimer's disease (AD), but the functional impact is difficult to measure in vivo. Task-evoked pupil dilation provides an index of locus coeruleus-norepinephrine function that might be altered in cognitively normal older adults with underlying AD pathology.
Keywords: attention, cognitive load, locus coeruleus, plasma biomarkers, preclinical Alzheimer's disease, pupillometry, visual search
Alzheimer's & dementia : the journal of the Alzheimer's Association
Journal Article
English
41996102
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