The pathogenesis of amyotrophic lateral sclerosis (ALS) involves a multistep process, with a central role for cortical hyperexcitability and misfolded protein accumulation. The glymphatic system mediates clearance of misfolded proteins, yet its role in modulating cortical excitability is unknown. This study aims to determine whether glymphatic dysfunction is associated with cortical hyperexcitability, thereby linking impaired protein clearance to excitotoxic neurodegeneration in ALS.
Keywords: ALS, Cortical hyperexcitability, DTI-ALPS index, Glymphatic flow
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Journal Article
English
42229207
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