Association between blood urea nitrogen-to-creatinine ratio trajectories and mortality in patients with severe pneumonia requiring invasive mechanical ventilation: a Medical Information Mart for Intensive Care IV (MIMIC-IV) database analysis. Journal Abstract - Guideline Central

Association between blood urea nitrogen-to-creatinine ratio trajectories and mortality in patients with severe pneumonia requiring invasive mechanical ventilation: a Medical Information Mart for Intensive Care IV (MIMIC-IV) database analysis.

Published: 2026 May 31

Authors

, , , , ,

Abstract

Once pneumonia patients progress to requiring invasive mechanical ventilation (IMV), mortality in the intensive care unit (ICU) increases substantially. The blood urea nitrogen-to-creatinine ratio (BUNCR) is a potential biomarker of catabolic stress in critically ill patients, yet its dynamic prognostic value in ICU-admitted pneumonia patients remains unclear. This study employed group-based trajectory modeling (GBTM) to explore the association between early dynamic changes in BUNCR and mortality.

Keywords: Invasive mechanical ventilation (IMV), blood urea nitrogen-to-creatinine ratio (BUNCR), mortality, severe pneumonia, trajectory modeling

Source

Journal of thoracic disease

Publication Type

Journal Article

Language

English

PubMed ID

42306717

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