Cystic fibrosis-related diabetes (CFRD) management is evolving as the CF population experiences increasing rates of overweight and obesity, particularly with widespread cystic fibrosis transmembrane conductance regulator (CFTR) modulator use. This article describes practical insights from implementing a pilot program evaluating injectable semaglutide, a GLP-1 receptor agonist (GLP-1 RA), in adults with CFRD. Our program followed 11 participants over 12 months, revealing important considerations for patient selection, monitoring protocols, and managing adverse effects in this unique population. While the majority of participants tolerated semaglutide well with clinically meaningful improvements in glycemic control, careful screening and close follow-up proved essential. These findings offer practical guidance for diabetes educators and clinicians considering GLP-1 RA therapy as an adjunct to insulin in carefully selected patients with CFRD.
Keywords: GLP-1 receptor agonist, cystic fibrosis, diabetes, diabetes education, glycemic control
Canadian journal of diabetes
Journal Article
English
42331284
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