Pyridoxine/pyridoxal-5'-phosphate repletion to improve outcomes of alcohol withdrawal syndrome and promote long-term abstinence: a hypothesis. Journal Abstract - Guideline Central

Pyridoxine/pyridoxal-5'-phosphate repletion to improve outcomes of alcohol withdrawal syndrome and promote long-term abstinence: a hypothesis.

Published: 2026 Jul 21

Authors

Abstract

Deficiency of pyridoxal-5-phosphate, the clinically measured and active form of pyridoxine (vitamin B6), is prevalent among those with alcohol use disorder. However, unlike thiamine, pyridoxal-5-phosphate is not routinely repleted. Evidence is presented that its repletion would improve outcomes of alcohol withdrawal syndrome and promote long-term abstinence.

Keywords: Alcohol use disorder, GABA, alcohol withdrawal, benzodiazepine, craving, epilepsy, glutamate, phenobarbital, pyridoxine, seizures

Source

Clinical toxicology (Philadelphia, Pa.)

Publication Type

Journal Article

Language

English

PubMed ID

42480097

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