Pre-operative injectable testosterone therapy is associated with increased five-year revision risk after total shoulder arthroplasty: a TriNetX database analysis.

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Authors

Abstract

Testosterone replacement therapy (TRT) has become increasingly prevalent among men and influences bone metabolism, muscle strength, inflammatory signaling, and pain perception. These factors may affect implant durability and long-term outcomes after primary total shoulder arthroplasty (TSA). While perioperative risks of hormonal therapies have been evaluated in other orthopedic populations, the relationship between pre-operative TRT exposure and long-term TSA outcomes remains poorly understood. The purpose of this study was to evaluate the association between pre-operative injectable TRT use and long-term post-operative outcomes following primary TSA.

Keywords: Injectable testosterone, Mechanical complications, Opioid use disorder, Post-operative outcomes, Shoulder arthroplasty revision, Shoulder pain, Testosterone replacement therapy, Total shoulder arthroplasty

Source

Journal of shoulder and elbow arthroplasty

Publication Type

Journal Article

Language

English

PubMed ID

42602516