Timing of hemoadsorption in sepsis: redefining early through mediator-guided therapy. Journal Abstract - Guideline Central

Timing of hemoadsorption in sepsis: redefining early through mediator-guided therapy.

Published: 2026 Aug 25

Authors

, ,

Abstract

Hemoadsorption is gaining acceptance as an adjunctive extracorporeal blood purification strategy in sepsis and septic shock; however, its clinical value remains contingent on two closely linked variables: when therapy is initiated and in whom it should be used. This review synthesizes the pathophysiological rationale, conceptual models of mediator removal, available devices, and clinical evidence for hemoadsorption in sepsis, with particular attention to patient selection.

Keywords: Cytokines, Endotoxin, Extracorporeal blood purification, Hemoadsorption, Hemoperfusion, Host response, Sepsis, Septic shock

Source

Journal of intensive care

Publication Type

Journal Article

Language

English

PubMed ID

42642780

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