Early Identification of a Cytokine-Low Immune Phenotype in Suspected Sepsis Using a Point-of-Care Whole-Blood TNF-α Release Assay. Journal Abstract - Guideline Central

Early Identification of a Cytokine-Low Immune Phenotype in Suspected Sepsis Using a Point-of-Care Whole-Blood TNF-α Release Assay.

Published: 2026 Aug 08

Authors

, , , , , , , , , , , , , , , , , , , ,

Abstract

Routine biomarkers and clinical scores do not directly assess functional immune responsiveness in suspected sepsis. We evaluated whether the TNF-α Release Assay (TARA), a whole-blood LPS-induced functional assay, is associated with an early cytokine-low immune phenotype in Emergency Department (ED) patients.

Keywords: TARA, TNF-α release assay, cytokine-low phenotype, emergency department, host response, innate immune hyporesponsiveness, sepsis, suspected sepsis

Source

Medical sciences (Basel, Switzerland)

Publication Type

Journal Article

Language

English

PubMed ID

42646601

MeSH terms

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