Febrile Ulceronecrotic Mucha-Habermann Disease - CME

CME

Description: An otherwise healthy 30-year-old man presented with a sudden onset, rapidly progressive, and painful skin eruption accompanied by fever lasting for 1 week (Figure 1). On physical examination, numerous erythematous papules, pustules, and ulceronecrotic and vesiculobullous lesions were observed diffusely on his face, trunk, and extremities, with an accentuation in the flexural areas (Figure 2). Oral and genital mucosa were affected. Serology test results for varicella-zoster virus, herpes simplex virus IgM antibodies, and rapid plasma reagin were negative. The mpox nucleic acid test yielded a negative result. Histopathological examination of a pustule revealed interface dermatitis with vesicle formation, dyskeratosis, epidermal necrosis, perivascular, and periadnexal infiltrations, suggestive of pityriasis lichenoides et varioliformis acuta (PLEVA). A diagnosis of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) was made. The patient received combination therapy with methotrexate and a tapering course of systemic corticosteroid. The patient’s temperature returned to normal, and the necrotic plaques gradually healed after 1 month.

Learning Objectives

Specialties: Internal Medicine - General, Family Medicine, Dermatology, Critical Care, Primary Care

Disclosures and Disclaimers: CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Accredited Providers

Credit Information

Credit Type	Units / Unit Type	Board
AMA PRA Category 1 Credit	1 Credits	ACCME- Accreditation Council for Continuing Medical Education