Thrombotic Thrombocytopenic Purpura
International Society on Thrombosis and HaemostasisPublished: September 25, 2025
- Key Points
- Diagnosis
- Treatment
- Tables
- Diagnosis in settings with timely access to plasma ADAMTS13 activity testing and for patients with a HIGH clinical suspicion of immune TTP
- Diagnosis in settings with timely access to plasma ADAMTS13 testing and for patients with INTERMEDIATE or LOW clinical suspicion of iTTP
- PLASMIC score or French score predicts the likelihood of severe ADAMTS13 deficiency in a suspected TTP
- Figures and Algorithms
- A suggested diagnostic and management strategy for patients with HIGH pretest probability of immune TTP
- A suggested diagnostic and management strategy for patients with LOW or INTERMEDIATE pretest probability of immune TTP
- Recommended decision tree for management of cTTP during remission (Update)
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