Inborn Errors of Immunity
American College of Allergy, Asthma, and Immunology, American Academy of Allergy, Asthma & ImmunologyPublished: June 16, 2026
- Key Points
- Diagnosis
- Management
- Tables
- International Union of Immunological Societies (IUIS) Classification of Human IEI 2024
- Examples of Secondary Causes of Immunodeficiency
- Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions for SCID
- Recommendations for the Care of Infants With SCID Diagnosis
- Detection Capabilities of Genetic Testing Platforms for Various Genomic Findings
- Examples of Specific Laboratory Testing for CIDs With or Without Syndromic Features
- Defects of Phagocyte Numbers and Function
- Examples of Diagnostic Assays for Defects of Innate Immune System Based on Infection Susceptibility (Complement Defects Not Included)
- Complement Deficiencies and Associated Infection and Diseases
- Examples of IEI Associated With Chronic Viral Infections and Specific Nonviral Infections That May Warrant Evaluation or Monitoring
- Examples of IEI Associated With Autoimmune Cytopenias
- Examples of IEIs Associated With Increased Cancer Risk
- Antibiotic Prophylaxis for Selected IEI
- Special Considerations for Antibiotic Treatment in At-Risk Individuals
- Management of Lung Disease
- Management of Gastrointestinal Disease
- Management of Dermatologic Disease
- Management of Rheumatologic and Musculoskeletal Disease
- Management of Hematologic/Oncologic Disease
- Vaccination Considerations in IEI
- Key Examples of Precision Medicine in IEI
- Food and Drug Administration (FDA)-Approved Precision Agents With Applications in IEI
- QoL Tools Used in IEI
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