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Therapy for Stage IV Non-Small-Cell Lung Cancer With Driver Alterations

Published: February 2024
Print Copy Information:
  • 16 pages
  • Spiral Bound
  • 80# Aqueous Coating
  • 4.25" x 7.25"
  • Ships in 5 – 10 business days
What's Inside
Bulk and Institutional Ordering
About the Authors
Additional Information
  • Key Points
  • Treatment
  • Algorithms
    • Second-Line and Subsequent Treatment Options for Patients with Stage IV NSCLC With KRAS G12C Alterations and HER2 Alterations
    • Treatment Options for Patients With Stage IV NSCLC With EGFR Alterations
    • First and Second Line Treatment Options for Patients With Stage IV NSCLC With ALK Rearrangements, ROS1 Rearrangements, BRAFV600E Mutations, MET Exon Skipping Mutations, RET Rearrangements, or NTRK Rearrangements
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Founded in 1964, the American Society of Clinical Oncology is the world's leading professional organization for physicians and oncology professionals caring for people with cancer.


Living guidelines are routinely updated guidelines that are developed for selected topic areas with rapidly evolving evidence that drives frequent change in clinical practice. These guidelines are updated on a regular schedule, based on the work of a standing panel that reviews the literature on a continuous basis.

This pocket guide is derived from recommendations in the American Society of Clinical Oncology Guideline. This resource is a practice tool based on ASCO® practice guidelines and is not intended to substitute for the independent professional judgment of the treating physician. Practice guidelines do not account for individual variation among patients. This pocket guide does not purport to suggest any particular course of medical treatment. Use of the practice guidelines and this resource are voluntary. The practice guidelines and additional information are available at
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