ASH Management of Venous Thromboembolism: Prevention and Treatment in Patients with Cancer Guideline Summary - Guideline Central

Design and created by Guideline Central in participation with the American Society of Hematology.

Document Overview

Document Title: Management of Venous Thromboembolism: Prevention and Treatment in Patients with Cancer

Authoring Society: American Society of Hematology

Document Publication Date: Feb 10, 2021

Page Last Reviewed/Updated: Mar 25, 2026

Document Type: Guideline

Country of Publication: United States

Full Text Freely Available: Yes

Full Text Guideline: ashpublications.org/bloodadvances/article/5/4/927/475194/American-Society-of-Hematology-2021-guidelines-for

Source Citation: Lyman GH, Carrier M, Ay C, Di Nisio M, Hicks LK, Khorana AA, Leavitt AD, Lee AYY, Macbeth F, Morgan RL, Noble S, Sexton EA, Stenehjem D, Wiercioch W, Kahale LA, Alonso-Coello P. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Adv. 2021 Feb 23;5(4):927-974. doi: 10.1182/bloodadvances.2020003442. Erratum in: Blood Adv. 2021 Apr 13;5(7):1953. PMID: 33570602; PMCID: PMC7903232.

Supplemental Implementation Resources

Document Scope, Criteria, and Use Cases

Scope: Management, Prevention, Treatment

Diseases/Conditions (MeSH): D054556 - Venous Thromboembolism

Keywords: Cancer patients, Clinical guidelines, Venous Thromboembolism, direct oral anticoagulants, eustachian tube disorders, hemorrahage, low-molecular-weight heparin, thromboprophylaxis

Inclusion Criteria: Male, Female, Adult, Older Adult

Health Care Settings: Ambulatory, Hospice, Hospital

Intended Users: Nurse, Nurse Practitioner, Physician, Physician Assistant, Social Worker

Recommendation Development Processes & Methodology

Number of Source Documents: 403

Literature Search Start Date: Thursday, February 25, 2016

Includes peer/external review process?: Yes

Includes public comment process?: No

Methodologist involvement?: Yes

Patient involvement?: No

Includes multi-disciplinary group?: Yes

Includes systematic review?: Yes

Grades quality of strength of evidence?: Yes

Grades quality of strength of recommendation?: Yes

Discloses funding source?: Yes

Discloses conflicts of interest?: Yes

Includes benefits/harms analysis with recommendations?: No