ASRM Subclinical Hypothyroidism in the Infertile Female Population Guideline Summary - Guideline Central
Recommendations
Document Overview

Subclinical Hypothyroidism in the Infertile Female Population

American Society for Reproductive Medicine


Publication Date: Sep 1, 2015

Page Last Updated: May 5, 2026

American Society for Reproductive Medicine Quality and Strength of Evidence

Quality of the Evidence
LevelDefinition
IEvidence obtained from at least one properly designed randomized controlled trial.
II-1Evidence from controlled trials without randomization Cohort or case-control studies Multiple time series dramatic uncontrolled experiments.
II-2Evidence obtained from well-designed controlled trials without randomization.
II-3Evidence obtained from multiple time series with or without the intervention. Dramatic results in uncontrolled trials might also be regarded as this type of evidence.
IIIOpinions of respected authorities, based on clinical experience, descriptive studies, or reports of expert committees.
Strength of Evidence
AThere is good evidence to support the recommendations, either for or against.
BThere is fair evidence to support the recommendations, either for or against.
CThere is insufficient evidence to support a recommendation, either for or against.

Document Overview

Document Title
Subclinical Hypothyroidism in the Infertile Female Population
Authoring Society

American Society for Reproductive Medicine

Document Publication Date
Sep 1, 2015
Page Last Reviewed/Updated
May 5, 2026
Document Type
Guideline
Country of Publication
United States
Full Text Freely Available
Yes
Full Text Guideline
www.fertstert.org/article/S0015-0282(15)00379-9/fulltext
Source Citation

Subclinical hypothyroidism in the infertile female population: a guideline

Fertility and Sterility, Volume 104, Issue 3, 545 - 553

Document Scope, Criteria, and Use Cases

Document Objectives
There is controversy regarding whether to treat subtle abnormalities of thyroid dysfunction in the infertile female patient. This guideline document reviews the risks and benefits of treating subclinical hypothyroidism in female patients with a history of infertility and miscarriage, as well as obstetrical and neonatal outcomes in this population.
Scope
Assessment and Screening, Management, Treatment
Diseases/Conditions (MeSH)

D007247 - Infertility, Female

D007246 - Infertility

D007037 - Hypothyroidism

D007037 - Hypothyroidism

D007246 - Infertility

D007247 - Infertility, Female

Keywords
hypothyroidism, infertility, levothyroxine, thyroid stimulating hormone (TSH)
Target Patient Population
Female patients who have subclinical hypothyroidism with a history of infertility and miscarriage
Inclusion Criteria
Female, Adult
Health Care Settings
Ambulatory, Outpatient
Intended Users
Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

Number of Source Documents
62
Literature Search End Date
Saturday, March 1, 2014
Includes peer/external review process?
Yes
Includes public comment process?
No
Methodologist involvement?
Yes
Patient involvement?
No
Includes multi-disciplinary group?
Yes
Includes systematic review?
Yes
Grades quality of strength of evidence?
Yes
Grades quality of strength of recommendation?
Yes
Discloses funding source?
No
Discloses conflicts of interest?
Yes
Includes benefits/harms analysis with recommendations?
No
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