HEMORR2HAGES Score for Major Bleeding Risk

Quantifies risk of hemorrhage in elderly patients with Atrial Fibrillation

Hepatic or Renal Disease

Ethanol (Alcohol) Abuse

Malignancy History

Older (Age > 75)

Reduced Platelet Count or Function

  • Includes aspirin use, any thrombocytopenia or blood dyscrasia, like hemophilia

Rebleeding Risk

  • History of past bleeding

Hypertension (Uncontrolled)


Genetic Factors

  • CYP 2C9 single-nucleotide polymorphisms

Excessive Fall Risk

Stroke History


Source: Gage BF, Yan Y, Milligan PE, et al. Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation. Am Heart J 2006; 151:713-9.